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Genetic Alteration That Triggers Prostate Cancer In Mice And Man Confirmed

Date:
January 29, 2008
Source:
Fred Hutchinson Cancer Research Center
Summary:
Scientists have confirmed that a molecular change found in human prostate cancers triggers the growth of prostate cancer in mice and in human cell lines. A significant proportion of human prostate cancers carry a chromosomal rearrangement that results in the overexpression of the ETS transcription factor ERG, a protein that controls gene expression. Until now, the functional significance of this event has been poorly understood.

A team of researchers led by Valeri Vasioukhin, Ph.D., and Peter Nelson, M.D., both investigators in the Human Biology Division at Fred Hutchinson Cancer Research Center, has confirmed that a molecular change found in human prostate cancers triggers the growth of prostate cancer in mice and in human cell lines.

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A significant proportion of human prostate cancers carry a chromosomal rearrangement that results in the overexpression of the ETS transcription factor ERG, a protein that controls gene expression. Until now, the functional significance of this event has been poorly understood.

Studying prostate cells in transgenic mice, Vasioukhin, Nelson and colleagues at the Hutchinson Center and the University of Washington found that up-regulation of ERG transcript initiates cancer growth. They found a similar effect in human prostate cells. They hypothesize that up-regulation of ERG in human prostate cancer activates cell-invasion programs, causing the displacement of basal cells by neoplastic epithelium, or cancerous tissue.

As such, they suggest that ERG should be considered as a target for prostate-cancer prevention or early therapeutic intervention.

These findings will be published Jan. 28 in the online early edition of the Proceedings of the National Academy of Sciences.


Story Source:

The above story is based on materials provided by Fred Hutchinson Cancer Research Center. Note: Materials may be edited for content and length.


Cite This Page:

Fred Hutchinson Cancer Research Center. "Genetic Alteration That Triggers Prostate Cancer In Mice And Man Confirmed." ScienceDaily. ScienceDaily, 29 January 2008. <www.sciencedaily.com/releases/2008/01/080129080715.htm>.
Fred Hutchinson Cancer Research Center. (2008, January 29). Genetic Alteration That Triggers Prostate Cancer In Mice And Man Confirmed. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2008/01/080129080715.htm
Fred Hutchinson Cancer Research Center. "Genetic Alteration That Triggers Prostate Cancer In Mice And Man Confirmed." ScienceDaily. www.sciencedaily.com/releases/2008/01/080129080715.htm (accessed October 25, 2014).

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