Featured Research

from universities, journals, and other organizations

Improved Prediction Of Prostate Cancer Outcome With New Model

Date:
February 4, 2008
Source:
BioMed Central
Summary:
Scientists are another step closer to understanding why some people suffer from life-threatening diseases such as cancer. A new model may enable more accurate prediction of the risk of prostate cancer progression. By combining the Gleason score (a pathological score given to prostate cancer based on its microscopic appearance) with structured data from biomarker assessments, the researchers have developed a model for predicting the likelihood of prostate cancer virulence.

Scientists are another step closer to understanding why some people suffer from life-threatening diseases such as cancer. New research reveals a model that may enable more accurate prediction of the risk of prostate cancer progression. By combining the Gleason score (a pathological score given to prostate cancer based on its microscopic appearance) with structured data from biomarker assessments, the researchers have developed a model for predicting the likelihood of prostate cancer virulence.

The research team from the University of Texas M. D. Anderson Cancer Center, led by Dr. Timothy McDonnell, used tissue microarrays with specimens covering the spectrum of low to high grade prostate cancer, to address several questions of clinical and pathological interest. The biomarkers evaluated in this study comprised well-characterized cell cycle and cell death regulators known to be variably expressed by prostate cancers. Significant differences in the molecular signatures were found among these varying grades of tumors, and a biostatistical model was developed using a limited number of molecular markers to enable a more accurate prediction of the risk of prostate cancer progression.

"We believe these findings will be of potential benefit to a substantial portion of the patient population diagnosed with early prostate cancer by providing valuable information regarding the risk of disease progression" says McDonnell. "With this type of information patients could be more appropriately managed based on their individual risk profile."

Healthcare professionals are increasingly turning to the use of genomic techniques to understand why some people are predisposed to certain conditions such as infections, addictions, and illnesses like diabetes, heart disease, and schizophrenia, while others are not. By employing these techniques, researchers and physicians could soon offer patients a more tailored and individual medical treatment program.

Journal reference: Biomarker Expression Patterns That Correlate With High Grade Features in Treatment Naive, Organ-confined Prostate Cancer. Timothy J McDonnell, Nikhil S Chari, Jeong Hee Cho-Vega, Patricia Troncoso, Xuemei Wang, Carlos E Bueso-Ramos, Kevin Coombes, Shawn Brisbay, Remigio Lopez, George Prendergast, Christopher Logothetis and Kim-Anh Do. BMC Medical Genomics (in press) http://www.biomedcentral.com/1755-8794/1/1/abstract


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Improved Prediction Of Prostate Cancer Outcome With New Model." ScienceDaily. ScienceDaily, 4 February 2008. <www.sciencedaily.com/releases/2008/01/080131082240.htm>.
BioMed Central. (2008, February 4). Improved Prediction Of Prostate Cancer Outcome With New Model. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2008/01/080131082240.htm
BioMed Central. "Improved Prediction Of Prostate Cancer Outcome With New Model." ScienceDaily. www.sciencedaily.com/releases/2008/01/080131082240.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins