Featured Research

from universities, journals, and other organizations

Genetic Variant Increases Risk Of Developing Schizophrenia In Women

Date:
February 19, 2008
Source:
Public Library of Science
Summary:
A complete scan of the human genome has revealed that a genetic variant in the Reelin gene increases the risk of developing schizophrenia in women only. Researchers who conducted the study in the Ashkenazi Jewish population, confirmed their findings by establishing a multinational collaboration that included populations and researchers from the United Kingdom, Ireland, United States, and China.

A complete scan of the human genome has revealed that a genetic variant in the Reelin gene increases the risk of developing schizophrenia in women only. Researchers from the Hebrew University of Jerusalem and the University of Oxford, who conducted the study in the Ashkenazi Jewish population, confirmed their findings by establishing a multinational collaboration that included populations and researchers from the United Kingdom, Ireland, United States, and China.

Heritability of schizophrenia has been well established through epidemiological studies in past years. However, efforts to identify the genes associated with this devastating disease, which affects about 1% of the human population, have encountered significant difficulties. Technological advances that allow the complete and efficient scanning of the entire genome present a new opportunity to address this challenge.

The authors analyzed 500,000 genetic variants distributed across the whole human genome in DNA from patients with schizophrenia and control subjects. By comparing the genomes of hundreds of patients with schizophrenia with those of healthy controls across several human populations, the researchers identified a gene that significantly increases the risk of developing the disease, but interestingly in women only.

This study represents significant progress in the study of schizophrenia with possible practical implications in the areas of disease diagnosis and drug discovery. Nevertheless, it is important to stress that these possibilities will require many years of additional research, and even then, success cannot be guaranteed.

CITATION: Shifman S, Johannesson M, Bronstein M, Chen SX, Collier DA, et al. (2008) Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet 4(2): e28. doi:10.1371/journal.pgen.0040028 http://genetics.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pgen.0040028


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Genetic Variant Increases Risk Of Developing Schizophrenia In Women." ScienceDaily. ScienceDaily, 19 February 2008. <www.sciencedaily.com/releases/2008/02/080215103330.htm>.
Public Library of Science. (2008, February 19). Genetic Variant Increases Risk Of Developing Schizophrenia In Women. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/02/080215103330.htm
Public Library of Science. "Genetic Variant Increases Risk Of Developing Schizophrenia In Women." ScienceDaily. www.sciencedaily.com/releases/2008/02/080215103330.htm (accessed July 23, 2014).

Share This




More Mind & Brain News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Do Obese Women Have 'Food Learning Impairment'?

Do Obese Women Have 'Food Learning Impairment'?

Newsy (July 18, 2014) Yale researchers tested 135 men and women, and it was only obese women who were deemed to have "impaired associative learning." Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins