Featured Research

from universities, journals, and other organizations

Brain Damage Occurs Within Minutes From The Onset Of A Stroke, Study Reveals

Date:
February 19, 2008
Source:
University of British Columbia
Summary:
Harmful changes to the brain's synaptic connections occur within the first three minutes following a stroke. The finding, using mouse models, suggests cardiac arrest and stroke in humans would trigger a similar chain of events. Stroke is caused by loss of blood flow to the brain and is a leading cause of death and disability in North America. Synapses are tiny brain switches that relay information from one neuron to another.

Scientists at the Brain Research Centre at the University of British Columbia and Vancouver Coastal Health Research Institute have found that harmful changes to the brain's synaptic connections occur within the first three minutes following a stroke.

Related Articles


The finding, using mouse models, published in the Journal of Neuroscience February 14, suggests cardiac arrest and stroke in humans would trigger a similar chain of events.  Stroke is caused by loss of blood flow to the brain and is a leading cause of death and disability in North America. Synapses are tiny brain switches that relay information from one neuron to another. 

“Damage to the brain’s synaptic connections occurs much sooner than expected,” says Tim Murphy, UBC Professor of Psychiatry, senior investigator at the Brain Research Centre, and a member of the Vancouver Coastal Health Research Institute. “Potentially, stroke or cardiac arrest patients have undergone major changes in the structure of their synapses before anyone could think about calling 911.”

Murphy, lead author of the study says, “although stroke can be treated within three hours of onset, the implications of this study are that considerable damage – some of which is irreversible – has occurred almost immediately after a stroke. Given these results, stroke prevention through management of risk factors should be given greater emphasis.”

Using high-resolution microscopy, scientists demonstrated that the structure and function of cortical synapses were severely compromised only one to three minutes after stroke during a massive wave of electrical discharge termed ischemic depolarization. Importantly, if blood flow was restored, as can occur using stroke treatments with clot-busting drugs, 94 per cent of all synaptic connections recovered from severe deformation. Further studies will examine the upper limits of blood flow restoration time and synaptic connection recovery.

The study suggests that even short duration loss of blood flow, (approximately one to three minutes) could lead to damaged synapses.  In humans, brief loss of brain blood flow can occur during medical procedures such as bypass surgery, which can trigger blood clots to enter the brain. Other conditions with brief recurrent loss of blood flow include transient ischemia attacks, or mini strokes.  For these situations Murphy suggests, “Strategies that control ischemic depolarization associated with stroke's effect on synapses would be fruitful avenues for future drug development.”

The work was funded by grants from the Canadian Institutes for Health Research, the Heart and Stroke Foundation of BC and the Yukon, and the Canadian Stroke Network.


Story Source:

The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.


Cite This Page:

University of British Columbia. "Brain Damage Occurs Within Minutes From The Onset Of A Stroke, Study Reveals." ScienceDaily. ScienceDaily, 19 February 2008. <www.sciencedaily.com/releases/2008/02/080218214642.htm>.
University of British Columbia. (2008, February 19). Brain Damage Occurs Within Minutes From The Onset Of A Stroke, Study Reveals. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2008/02/080218214642.htm
University of British Columbia. "Brain Damage Occurs Within Minutes From The Onset Of A Stroke, Study Reveals." ScienceDaily. www.sciencedaily.com/releases/2008/02/080218214642.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins