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Vitamin E May Increase Tuberculosis Risk In Male Smokers With High Vitamin C Intake

Date:
February 21, 2008
Source:
University of Helsinki
Summary:
Six-year vitamin E supplementation increased tuberculosis risk by in male smokers who had high dietary vitamin C intake, according to a new study. Previous studies had suggested that vitamin E might improve the immune system.
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Six-year vitamin E supplementation increased tuberculosis risk by 72% in male smokers who had high dietary vitamin C intake, but vitamin E had no effect on those who had low dietary vitamin C intake, according to a study published in the British Journal of Nutrition.

Previous studies had suggested that vitamin E might improve the immune system. In animal studies vitamin E seemed to protect against various infections.

Harri Hemila and Jaakko Kaprio, of the University of Helsinki, Helsinki, Finland, studied whether vitamin E supplementation might decrease the risk of tuberculosis. They analyzed the data of the randomized trial (Alpha-Tocopherol Beta-Carotene Cancer Prevention Study) which was conducted in Finland between 1985-1993 and included male smokers aged 50-69 years. There were 174 cases of tuberculosis in 29,023 participants during the 6-year supplementation of 50 mg/day vitamin E.

The effect of vitamin E on tuberculosis risk was modified by the intake of vitamin C in diet. Vitamin E had no effect on participants who had dietary vitamin C intake less than 90 mg/day. Unexpectedly, vitamin E supplementation increased tuberculosis risk by 72% in those who had dietary vitamin C intake over 90 mg/day. The most dramatic increase in tuberculosis risk by vitamin E was restricted to a one-year period after the initiation of supplementation.

The US nutritional recommendations, issued by the prestigious Institute of Medicine, consider that vitamin E is safe in amounts up to 1000 mg/day. This new study suggests that in some population groups vitamin E supplementation may be harmful at a substantially lower dose, 50 mg/day.

The researchers concluded that "the consumption of vitamin E supplements by the general population should be discouraged because there is evidence of harm for some people."

Report available at: http://dx.doi.org/10.1017/S0007114508923709


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The above post is reprinted from materials provided by University of Helsinki. Note: Materials may be edited for content and length.


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University of Helsinki. "Vitamin E May Increase Tuberculosis Risk In Male Smokers With High Vitamin C Intake." ScienceDaily. ScienceDaily, 21 February 2008. <www.sciencedaily.com/releases/2008/02/080221101425.htm>.
University of Helsinki. (2008, February 21). Vitamin E May Increase Tuberculosis Risk In Male Smokers With High Vitamin C Intake. ScienceDaily. Retrieved July 7, 2015 from www.sciencedaily.com/releases/2008/02/080221101425.htm
University of Helsinki. "Vitamin E May Increase Tuberculosis Risk In Male Smokers With High Vitamin C Intake." ScienceDaily. www.sciencedaily.com/releases/2008/02/080221101425.htm (accessed July 7, 2015).

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