Featured Research

from universities, journals, and other organizations

New Method To Create An Artificial Heart May Hold Promise For Transplant Surgery

Date:
February 25, 2008
Source:
Nature Medicine
Summary:
A method to create an artificial heart using the extracellular matrix of an actual heart that has been stripped of all cells may hold promise for its use in transplant surgery. About 3,000 patients in the United States await a donor heart; worldwide, 22 million people live with heart failure. An artificial heart is a theoretical alternative for transplantation.

A method to create an artificial heart using the extracellular matrix of an actual heart that has been stripped of all cells may hold promise for its use in transplant surgery.

Related Articles


About 3,000 patients in the United States await a donor heart; worldwide, 22 million people live with heart failure. An artificial heart is a theoretical alternative for transplantation. Generating an artificial heart requires engineering of the cardiac architecture, appropriate cellular constituents and pump function.

Doris Taylor and colleagues removed all cells from rat hearts by bathing them with detergents. This manipulation allowed them to preserve the underlying extracellular matrix, obtaining a heart ‘scaffold’ with blood vessels, competent heart valves and intact atrial and ventricular geometry.

To mimic cardiac cell composition, the authors seeded these scaffolds with cardiac cells and maintained them in culture conditions that simulated cardiac physiology. Four days later, they observed contractions and, by day 8, their constructs could generate pump function equivalent to about 2% of adult heart function.

Although the in vivo functionality of this artificial heart has yet to be explored, this approach may hold promise for its use in transplant surgery.

Journal reference: Harald C Ott, Thomas S Matthiesen, Saik-Kia Goh, Lauren D Black, Stefan M Kren, Theoden I Netoff & Doris A Taylor. Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart pp 213 - 221 Nature Medicine. Published online: 13 January 2008 | doi 10.1038/nm1684


Story Source:

The above story is based on materials provided by Nature Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Nature Medicine. "New Method To Create An Artificial Heart May Hold Promise For Transplant Surgery." ScienceDaily. ScienceDaily, 25 February 2008. <www.sciencedaily.com/releases/2008/02/080224141414.htm>.
Nature Medicine. (2008, February 25). New Method To Create An Artificial Heart May Hold Promise For Transplant Surgery. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2008/02/080224141414.htm
Nature Medicine. "New Method To Create An Artificial Heart May Hold Promise For Transplant Surgery." ScienceDaily. www.sciencedaily.com/releases/2008/02/080224141414.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins