Featured Research

from universities, journals, and other organizations

New Method To Create An Artificial Heart May Hold Promise For Transplant Surgery

Date:
February 25, 2008
Source:
Nature Medicine
Summary:
A method to create an artificial heart using the extracellular matrix of an actual heart that has been stripped of all cells may hold promise for its use in transplant surgery. About 3,000 patients in the United States await a donor heart; worldwide, 22 million people live with heart failure. An artificial heart is a theoretical alternative for transplantation.

A method to create an artificial heart using the extracellular matrix of an actual heart that has been stripped of all cells may hold promise for its use in transplant surgery.

About 3,000 patients in the United States await a donor heart; worldwide, 22 million people live with heart failure. An artificial heart is a theoretical alternative for transplantation. Generating an artificial heart requires engineering of the cardiac architecture, appropriate cellular constituents and pump function.

Doris Taylor and colleagues removed all cells from rat hearts by bathing them with detergents. This manipulation allowed them to preserve the underlying extracellular matrix, obtaining a heart ‘scaffold’ with blood vessels, competent heart valves and intact atrial and ventricular geometry.

To mimic cardiac cell composition, the authors seeded these scaffolds with cardiac cells and maintained them in culture conditions that simulated cardiac physiology. Four days later, they observed contractions and, by day 8, their constructs could generate pump function equivalent to about 2% of adult heart function.

Although the in vivo functionality of this artificial heart has yet to be explored, this approach may hold promise for its use in transplant surgery.

Journal reference: Harald C Ott, Thomas S Matthiesen, Saik-Kia Goh, Lauren D Black, Stefan M Kren, Theoden I Netoff & Doris A Taylor. Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart pp 213 - 221 Nature Medicine. Published online: 13 January 2008 | doi 10.1038/nm1684


Story Source:

The above story is based on materials provided by Nature Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Nature Medicine. "New Method To Create An Artificial Heart May Hold Promise For Transplant Surgery." ScienceDaily. ScienceDaily, 25 February 2008. <www.sciencedaily.com/releases/2008/02/080224141414.htm>.
Nature Medicine. (2008, February 25). New Method To Create An Artificial Heart May Hold Promise For Transplant Surgery. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2008/02/080224141414.htm
Nature Medicine. "New Method To Create An Artificial Heart May Hold Promise For Transplant Surgery." ScienceDaily. www.sciencedaily.com/releases/2008/02/080224141414.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins