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Acid-seeking 'Warheads' Promise Safer, More Effective Cancer Weapons

Date:
February 27, 2008
Source:
American Chemical Society
Summary:
Researchers in California report development of an anti-cancer 'warhead' that targets the acidic signature of tumor cells in much the same way that heat-seeking missiles seek and destroy military targets that emit heat. These acid-seeking substances are not toxic to healthy cells, and represent a new class of potentially safer, more effective anti-cancer drugs, they say.

Researchers in California report development of an anti-cancer "warhead" that targets the acidic signature of tumor cells in much the same way that heat-seeking missiles seek and destroy military targets that emit heat. These acid-seeking substances are not toxic to healthy cells, and represent a new class of potentially safer, more effective anti-cancer drugs, they say.

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For years, scientists tried to develop anti-cancer drugs based on enediynes, a powerful class of natural, tumor-fighting agents derived from soil bacteria. However, as these substances kill both cancerous and healthy cells, their effectiveness as anti-cancer drugs is limited.

In the new study, Elfi Kraka and colleagues describe making unusual substances that become highly active only in the presence of low pH levels, or acidic environments. Since cancer cells have highly acidic environments in comparison to normal cells, compounds containing these substances -- called dynemicin-amidines (DADs) -- target and destroy tumor cells without affecting healthy cells, the researchers say.

The substances represent "the design of the first nontoxic enediyne antitumor drugs based on the DAD principle," the report states.

The article, "Design of a New Warhead for the Natural Enediyne Dynemicin A. An Increase of Biological Activity,"   is scheduled for the March 6 issue of ACS' The Journal of Physical Chemistry B.  doi. /10.1021/jp0773536


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The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Acid-seeking 'Warheads' Promise Safer, More Effective Cancer Weapons." ScienceDaily. ScienceDaily, 27 February 2008. <www.sciencedaily.com/releases/2008/02/080225092524.htm>.
American Chemical Society. (2008, February 27). Acid-seeking 'Warheads' Promise Safer, More Effective Cancer Weapons. ScienceDaily. Retrieved November 29, 2014 from www.sciencedaily.com/releases/2008/02/080225092524.htm
American Chemical Society. "Acid-seeking 'Warheads' Promise Safer, More Effective Cancer Weapons." ScienceDaily. www.sciencedaily.com/releases/2008/02/080225092524.htm (accessed November 29, 2014).

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