Featured Research

from universities, journals, and other organizations

Acid-seeking 'Warheads' Promise Safer, More Effective Cancer Weapons

Date:
February 27, 2008
Source:
American Chemical Society
Summary:
Researchers in California report development of an anti-cancer 'warhead' that targets the acidic signature of tumor cells in much the same way that heat-seeking missiles seek and destroy military targets that emit heat. These acid-seeking substances are not toxic to healthy cells, and represent a new class of potentially safer, more effective anti-cancer drugs, they say.

Researchers in California report development of an anti-cancer "warhead" that targets the acidic signature of tumor cells in much the same way that heat-seeking missiles seek and destroy military targets that emit heat. These acid-seeking substances are not toxic to healthy cells, and represent a new class of potentially safer, more effective anti-cancer drugs, they say.

For years, scientists tried to develop anti-cancer drugs based on enediynes, a powerful class of natural, tumor-fighting agents derived from soil bacteria. However, as these substances kill both cancerous and healthy cells, their effectiveness as anti-cancer drugs is limited.

In the new study, Elfi Kraka and colleagues describe making unusual substances that become highly active only in the presence of low pH levels, or acidic environments. Since cancer cells have highly acidic environments in comparison to normal cells, compounds containing these substances -- called dynemicin-amidines (DADs) -- target and destroy tumor cells without affecting healthy cells, the researchers say.

The substances represent "the design of the first nontoxic enediyne antitumor drugs based on the DAD principle," the report states.

The article, "Design of a New Warhead for the Natural Enediyne Dynemicin A. An Increase of Biological Activity," is scheduled for the March 6 issue of ACS' The Journal of Physical Chemistry B. doi. /10.1021/jp0773536


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Acid-seeking 'Warheads' Promise Safer, More Effective Cancer Weapons." ScienceDaily. ScienceDaily, 27 February 2008. <www.sciencedaily.com/releases/2008/02/080225092524.htm>.
American Chemical Society. (2008, February 27). Acid-seeking 'Warheads' Promise Safer, More Effective Cancer Weapons. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2008/02/080225092524.htm
American Chemical Society. "Acid-seeking 'Warheads' Promise Safer, More Effective Cancer Weapons." ScienceDaily. www.sciencedaily.com/releases/2008/02/080225092524.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins