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First Global Malaria Map In Decades Shows Reduced Risk

Date:
February 27, 2008
Source:
University of Florida
Summary:
About 35 percent of the world's population is at risk of contracting deadly malaria, but many people are at a lower risk than previously thought, raising hope that the disease could be seriously reduced or eliminated in parts of the world.
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P. falciparum Malaria Risk Defined by Annual Parasite Incidence (top), Temperature, and Aridity (bottom).
Credit: The Limits and Intensity of Plasmodium falciparum Transmission: Implications for Malaria Control and Elimination Worldwide Guerra CA, Gikandi PW, Tatem AJ, Noor AM, Smith DL, et al. PLoS Medicine Vol. 5, No. 2, e38 doi:10.1371/journal.pmed.0050038

About 35 percent of the world's population is at risk of contracting deadly malaria, but many people are at a lower risk than previously thought, raising hope that the disease could be seriously reduced or eliminated in parts of the world.

So concludes a group of researchers, including a scientist in the University of Florida Emerging Pathogens Institute, who spent three years producing the first spatial map of global malaria risk in four decades.

The Malaria Atlas Project, or MAP, found that 2.37 billion people were at risk of contracting malaria from Plasmodium faciparum, the most deadly malaria parasite for humans transmitted through the bites of infected Anopheles mosquitoes. Of that number, about 1 billion people live under a much lower risk of infection than was assumed under the previous historical maps. The lower than expected risk extends across Central and South America, Asia and even parts of Africa, the continent where malaria kills the vast majority of its victims and where risk has historically been classified as universally high.

The MAP also highlights potential problems facing countries currently aiming to eliminate malaria. For example, Saudi Arabia is currently providing substantial financial support for the elimination of malaria in its neighbour, Yemen. However, the new research shows how high rates of population inflow from Somalia will pose a continued concern due to the potential reintroduction of the parasite. Similar dilemmas are faced by countries in south east Asia.

"This gives some hope of pursuing malaria elimination because the prevalence isn't as universally high as many people suppose," said David Smith, a UF associate professor of zoology and a co-author of the paper. "It's reasonable to think we can reduce or interrupt transmission in many places, but the prospects for success will improve if we make plans that are based on good information about malaria's distribution."

The MAP effort, a collaboration between Oxford University and the Kenyan Medical Research Institute, compiled information from national health statistics, tourist travel advisories, climate, mosquito vectors and surveys of malaria infection in nearly 5,000 communities and 87 countries. The project also incorporated information about how climatic conditions affect mosquito life cycles, and thus the likelihood of active transmission.

"One of my contributions was to help standardize prevalence estimates," Smith said.

The new map is important in part because it offers hope that malaria could be eliminated in certain areas using currently available tools, such as bed nets treated with insecticide that kills mosquitoes, the researchers said. It will also help donors and international agencies target investments in control measures where they are most likely to achieve the biggest gains.

More than 500 million cases of malaria are reported annually. Of those afflicted, about one million die; 80 percent of them are children in sub-Saharan Africa.

"Making data and maps more accessible on the worldwide web is a large part of the MAP's philosophy of getting the science accessed, critiqued and used by a much wider range of users," said the lead author of the paper, Carlos Guerra, of the University of Oxford.

Journal reference: Guerra CA, Gikandi PW, Tatem AJ, Noor AM, Smith DL, et al. (2008) The limits and intensity of Plasmodium falciparum transmission: Implications for malaria control and elimination worldwide. PLoS Med 5(2): e38 (doi=10.1371/journal.pmed.0050038)

The research was funded by the Wellcome Trust. In accordance with the trust's philosophy on open access, all the data and techniques tapped in the MAP are freely accessible via the project's Web site at http://www.map.ox.ac.uk.


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The above post is reprinted from materials provided by University of Florida. Note: Materials may be edited for content and length.


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University of Florida. "First Global Malaria Map In Decades Shows Reduced Risk." ScienceDaily. ScienceDaily, 27 February 2008. <www.sciencedaily.com/releases/2008/02/080225213650.htm>.
University of Florida. (2008, February 27). First Global Malaria Map In Decades Shows Reduced Risk. ScienceDaily. Retrieved July 6, 2015 from www.sciencedaily.com/releases/2008/02/080225213650.htm
University of Florida. "First Global Malaria Map In Decades Shows Reduced Risk." ScienceDaily. www.sciencedaily.com/releases/2008/02/080225213650.htm (accessed July 6, 2015).

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