Featured Research

from universities, journals, and other organizations

New Genetic Association With Schizophrenia Discovered

Date:
February 29, 2008
Source:
Elsevier
Summary:
Schizophrenia emerges from an altered pattern of brain development, and researchers continue to search for the genes that cause the brain to develop along a path that ultimately leads to schizophrenia.

Schizophrenia emerges from an altered pattern of brain development, and researchers continue to search for the genes that cause the brain to develop along a path that ultimately leads to schizophrenia. Researchers have now discovered a new genetic link to schizophrenia.

A prior genetic mapping study indicated that a particular gene, multiple epidermal growth factor-like domains 10 or MEGF10, may be associated with schizophrenia. In this new paper, Chen and colleagues directly studied this particular MEGF10 gene in both schizophrenia patients and healthy control subjects. They found that a variant of the MEGF10 gene is associated with the heritable risk for schizophrenia in family-based and case-control genetic studies. Further, the MEGF10 gene appears to be expressed to a greater extent in post-mortem brain tissue from individuals diagnosed with schizophrenia compared to tissue from a group of unaffected individuals.

Dr. Xiangning Chen, corresponding author for this article* and assistant professor of psychiatry and human genetics in the Virginia Commonwealth University School of Medicine, explains that "the significance of the paper is that it provides evidence that a gene, i.e. MEGF10, directly involved in apoptosis is found associated with schizophrenia. It has long been speculated that dysfunction of apoptosis may be a cause of schizophrenia, but there [has been] little direct evidence." Apoptosis is an important biological process of programmed cell death in humans and other complex organisms, and abnormal apoptotic processes have been implicated in a variety of diseases.

John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, comments on the curiosity of the association between schizophrenia and the MEGF10 gene, which influences the development of skin cells (the epidermis): "One clue may be that nerve cells and skin cells are derived from the same type of primitive cells early in the development of the embryo. Another link may be that features of epidermal development, such as the development of fingerprints, are abnormal in schizophrenia."

The findings of this study indicate that it may be important for the field of schizophrenia research to more intensively study MEGF10, to understand how it influences brain development, and how it might be related to the treatment of schizophrenia.

*The article is "MEGF10 Association with Schizophrenia" appears in Biological Psychiatry, Volume 63, Issue 5 (March 1, 2008), published by Elsevier. it is authored by Xiangning Chen, Xu Wang, Qi Chen, Vernell Williamson, Edwin van den Oord, Brion S. Maher, F. Anthony O'Neill, Dermot Walsh and Kenneth S. Kendler.


Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Cite This Page:

Elsevier. "New Genetic Association With Schizophrenia Discovered." ScienceDaily. ScienceDaily, 29 February 2008. <www.sciencedaily.com/releases/2008/02/080228093212.htm>.
Elsevier. (2008, February 29). New Genetic Association With Schizophrenia Discovered. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2008/02/080228093212.htm
Elsevier. "New Genetic Association With Schizophrenia Discovered." ScienceDaily. www.sciencedaily.com/releases/2008/02/080228093212.htm (accessed October 2, 2014).

Share This



More Mind & Brain News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Stopping School Violence

Stopping School Violence

Ivanhoe (Oct. 1, 2014) A trauma doctor steps out of the hospital and into the classroom to teach kids how to calmly solve conflicts, avoiding a trip to the ER. Video provided by Ivanhoe
Powered by NewsLook.com
Pineal Cysts: Debilitating Pain

Pineal Cysts: Debilitating Pain

Ivanhoe (Oct. 1, 2014) A tiny cyst in the brain that can cause debilitating symptoms like chronic headaches and insomnia, and the doctor who performs the delicate surgery to remove them. Video provided by Ivanhoe
Powered by NewsLook.com
Burning Away Brain Tumors

Burning Away Brain Tumors

Ivanhoe (Oct. 1, 2014) Doctors are 'cooking' brain tumors. Hear how this new laser-heat procedure cuts down on recovery time. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins