Featured Research

from universities, journals, and other organizations

Alcohol Intake Increases Risk Of Hypertension, High Blood Pressure In Certain Populations

Date:
March 6, 2008
Source:
University of Bristol
Summary:
The relationship between heavy drinking and hypertension is more significant than previously thought according to a new analysis of recent studies. Individuals who drink on a regular basis have a systolic blood pressure around 7 mmHg higher than that of people who do not drink.

Previous observational studies have reported that heavy alcohol intake is a risk factor for hypertension but such studies may be confounded by factors such as diet, smoking, exercise levels and socio-economic position. Clinical trials exploring the link are difficult to implement and have limited follow-up time.

The Bristol study, led by Dr Sarah Lewis of the University's Department of Social Medicine, took a different approach focused on people who have a mutation on a gene which affects their body's ability to eliminate alcohol.

Alcohol is initially metabolised to an intermediate compound, acetaldehyde, which is further metabolised and then eliminated from the body. The major enzyme responsible for this elimination is alcohol dehydrohenase 2 (ALDH2).

In some people, a genetic mutation leads to an inability to metabolize acetaldehyde and causes an accumulation of acetaldehyde after alcohol intake. This mutation is common in some Asian populations and results in facial flushing after consumption of alcohol coupled with intense nausea, drowsiness, headache and other unpleasant symptoms. People with this mutation therefore drink much less than those without it

The researchers looked at the ALDH2 genotype, comparing the blood pressure of those who have this mutation -- the *2 *2 genotype -- with those who do not -- the *1 *1 genotype.

The study found that individuals with the *1 *1 genotype, who had an alcohol intake of around 3 units per day, had strikingly higher blood pressure than those with the *2 *2 genotype, who tend to drink only very small amounts, or no alcohol.

Dr Lewis said: "This study shows that alcohol intake may increase blood pressure to a much greater extent, even among moderate drinkers, than previously thought. Large-scale replication studies are required to confirm this finding and to improve the precision of our estimates."

Journal reference: Chen L, Davey Smith G, Harbord R, Lewis SJ (2008) Alcohol and blood pressure: A systematic review implementing a mendelian randomization approach. PLoS Med 5(3): e52. doi=10.1371/journal.pmed.0050052


Story Source:

The above story is based on materials provided by University of Bristol. Note: Materials may be edited for content and length.


Cite This Page:

University of Bristol. "Alcohol Intake Increases Risk Of Hypertension, High Blood Pressure In Certain Populations." ScienceDaily. ScienceDaily, 6 March 2008. <www.sciencedaily.com/releases/2008/03/080304075730.htm>.
University of Bristol. (2008, March 6). Alcohol Intake Increases Risk Of Hypertension, High Blood Pressure In Certain Populations. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2008/03/080304075730.htm
University of Bristol. "Alcohol Intake Increases Risk Of Hypertension, High Blood Pressure In Certain Populations." ScienceDaily. www.sciencedaily.com/releases/2008/03/080304075730.htm (accessed August 22, 2014).

Share This




More Mind & Brain News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Charter Schools Alter Post-Katrina Landscape

Charter Schools Alter Post-Katrina Landscape

AP (Aug. 20, 2014) Nine years after Hurricane Katrina, charter schools are the new reality of public education in New Orleans. The state of Louisiana took over most of the city's public schools after the killer storm in 2005. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins