Featured Research

from universities, journals, and other organizations

Offspring Of Parents Who Both Have Alzheimer's Disease May Be More Likely To Develop The Illness

Date:
March 11, 2008
Source:
JAMA and Archives Journals
Summary:
Adult-age offspring of parents who have both been diagnosed with Alzheimer's disease appear to have an increased risk of developing the disease compared with the general population, according to a new report.

Adult-age offspring of parents who have both been diagnosed with Alzheimer's disease appear to have an increased risk of developing the disease compared with the general population, according to a new report.

Related Articles


"Alzheimer's disease is a common cause of dementia in the U.S. population and the leading cause of cognitive impairment in the elderly population," according to background information in the article. Identifying genes in Alzheimer's disease patients can help detect others who are at risk for the condition. "Because Alzheimer's disease is so common in the general population, it is not uncommon for both spouses to develop the disease. Offspring of two such affected individuals would presumably carry a higher burden of these Alzheimer's disease-associated genes."

Suman Jayadev, M.D., of the University of Washington, Seattle, and colleagues studied the frequency of Alzheimer's disease in adult children of 111 families in which both parents had been clinically diagnosed with the disease. Ages at onset of dementia were also noted.

Of the 297 offspring who reached adulthood, 22.6 percent developed Alzheimer's disease compared with an estimated 6 percent to 13 percent of the general population. The average age at onset for children of couples with the illness was 66.3. The risk of developing the disease increased with age with 31 percent of those older than age 60 affected and 41.8 percent of those older than age 70 affected. "Of the 240 unaffected individuals, 189 (78.8 percent) had not yet reached age 70 years, suggesting that the incidence of Alzheimer's disease (22.6 percent) is an underestimation of the final incidence rate of Alzheimer's disease in this population," the authors write.

Having additional family members with Alzheimer's disease did not increase the risk of developing the disease, but was associated with a younger age at onset for those who did develop the illness. Children with no history of the disease beyond the parents had an older age at onset (72 years) compared with those who had one parent with family history of the disease (60 years) or both parents with family history of the illness (57 years).

"The role of family history and the specific genes involved in this phenomenon require a better definition," the authors conclude. "Families with a significant Alzheimer's disease history may be more likely to be referred to an Alzheimer's disease research center and, thus, the present patients may be 'enriched' for a particularly Alzheimer's disease-prone subgroup. Following these families as the offspring continue to age will provide increasingly informative data."

Journal reference: Arch Neurol. 2008;65[3]:373-378.

This study was supported by grants from the National Institute on Aging/National Institutes of Health and by Veterans Affairs research funds.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Offspring Of Parents Who Both Have Alzheimer's Disease May Be More Likely To Develop The Illness." ScienceDaily. ScienceDaily, 11 March 2008. <www.sciencedaily.com/releases/2008/03/080310164920.htm>.
JAMA and Archives Journals. (2008, March 11). Offspring Of Parents Who Both Have Alzheimer's Disease May Be More Likely To Develop The Illness. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2008/03/080310164920.htm
JAMA and Archives Journals. "Offspring Of Parents Who Both Have Alzheimer's Disease May Be More Likely To Develop The Illness." ScienceDaily. www.sciencedaily.com/releases/2008/03/080310164920.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
New Hormone Could Protect Against Diabetes And Weight Gain

New Hormone Could Protect Against Diabetes And Weight Gain

Newsy (Mar. 4, 2015) A newly discovered hormone mimics the effects of exercise, protecting against diabetes and weight gain. Video provided by Newsy
Powered by NewsLook.com
Mount Everest Has a Poop Problem

Mount Everest Has a Poop Problem

Buzz60 (Mar. 4, 2015) With no bathrooms to use, climbers of Mount Everest have been leaving human waste on the mountain for years, and it&apos;s becoming a health issue. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com
The Best Tips to 'Skinny' Your Home

The Best Tips to 'Skinny' Your Home

Buzz60 (Mar. 4, 2015) If you&apos;re looking to reach your health goals this season, there are a few simple tips to help you spring clean your space and improve your nutrition. Krystin Goodwin (@krystingoodwin) has the skinny on keeping a healthy home. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins