Featured Research

from universities, journals, and other organizations

Radiologists Use Special MRI To Identify Brain Cancer Early

Date:
March 26, 2008
Source:
Radiological Society of North America
Summary:
A special type of magnetic resonance imaging can depict changes in blood volume in the brain that often precede cancerous transformation of brain tumors, according to a new study.

A special type of magnetic resonance imaging (MRI) can depict changes in blood volume in the brain that often precede cancerous transformation of brain tumors, according to a new study.

"We found that increases in blood volume within the tumor measured noninvasively by perfusion MRI precede other markers of malignant transformation by a year or more," said study co-author Adam Waldman, Ph.D., M.R.C.P., F.R.C.R., consultant neuroradiologist and imaging research director at Imperial College NHS Trust and honorary senior lecturer at Imperial College and University College, London.

Low-grade gliomas are primary brain tumors that grow slowly over several years. Eventually, almost all low-grade gliomas progress to high-grade gliomas, which carry a poor prognosis.

"Patients with low-grade gliomas are often young and may remain clinically well for many years but, at an unpredictable time their tumor will transform to an aggressively high-grade glioma," Dr. Waldman said.

For the study, the researchers performed perfusion MRI on 13 patients with low-grade gliomas to determine whether relative cerebral blood volume (rCBV) changes are an indicator of future malignant transformation.

Brain tumors can bring about the formation of new blood vessels, a process known as angiogenesis. These vessels are abnormal and lead to changes in blood volume and flow. Using perfusion MRI, radiologists can detect these changes well before they become apparent on contrast-enhanced MR images.

The patients underwent perfusion MRI and contrast-enhanced MRI every six months for up to three years. Seven patients progressed to high-grade, malignant gliomas between six and 36 months. In the six patients whose disease remained stable, rCBV remained relatively stable, increasing from a mean level of 1.31 at the beginning of the study to 1.52 over the follow-up period. However, in the patients exhibiting tumor transformation, mean rCBV increased progressively from 1.94 at study entry to 3.14 twelve months prior to transformation, to 3.65 six months prior to transformation and to 5.36 at the time transformation was diagnosed.

These findings suggest that significant changes in rCBV represent an important marker of malignant change in gliomas and reflect the earliest stages of the transformation process. Further, the data support the likelihood that the cellular processes underlying malignant transformation may occur 12 months or more before visible on contrast MRI.

"We have shown that perfusion MRI provides a noninvasive means of assessing the risk of transformation in individual patients," Dr. Waldman said. "Increasing perfusion can be regarded as an early warning sign of impending malignant transformation that can assist radiologists in identifying those patients most likely to benefit from earlier or more aggressive treatment."

Journal reference: "Low-Grade Gliomas: Do Changes in rCBV Measurements at Longitudinal Perfusion-weighted MR Imaging Predict Malignant Transformation?" Collaborating with Dr. Waldman were Nasuda Danchaivijitr, M.D., Daniel J. Tozer, Ph.D., Christopher E. Benton, B.Sc., Gisele Brasil Caseiras, M.D., Paul S. Tofts, Ph.D., Jeremy H. Rees, Ph.D., F.R.C.P., and H. Rolf Jδger, M.D., F.R.C.R.  


Story Source:

The above story is based on materials provided by Radiological Society of North America. Note: Materials may be edited for content and length.


Cite This Page:

Radiological Society of North America. "Radiologists Use Special MRI To Identify Brain Cancer Early." ScienceDaily. ScienceDaily, 26 March 2008. <www.sciencedaily.com/releases/2008/03/080325083333.htm>.
Radiological Society of North America. (2008, March 26). Radiologists Use Special MRI To Identify Brain Cancer Early. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/03/080325083333.htm
Radiological Society of North America. "Radiologists Use Special MRI To Identify Brain Cancer Early." ScienceDaily. www.sciencedaily.com/releases/2008/03/080325083333.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) — China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins