Featured Research

from universities, journals, and other organizations

Inhibition of Chemokine Receptor Activation May Improve Head and Neck Cancer Therapies, Study Suggests

Date:
March 26, 2008
Source:
Journal of the National Cancer Institute
Summary:
Squamous cell cancers of the head and neck that express a cell surface receptor, called CCR7, are less likely to respond to current therapies. Combining drugs that block this receptor with existing agents might improve patient outcomes.

Squamous cell cancers of the head and neck that express a cell surface receptor, called CCR7, are less likely to respond to current therapies. Combining drugs that block this receptor with existing agents might improve patient outcomes.

Robert L. Ferris, M.D., Ph.D., of the University of Pittsburgh Cancer Institute and colleagues previously found that the chemokine receptor 7 (CCR7) is frequently active in metastatic squamous cell cancers of the head and neck.

In the current study, Ferris and colleagues used cancer cell lines and tumor cells isolated from primary and metastatic head and neck tumors to examine patterns of CCR7 activation. They also looked for expression of the ligands that stimulate the receptor.

Treatment of cells isolated from metastatic tumors with an anti-CCR7 antibody, which blocked activation of the receptor, reduced cell survival by 31 percent, compared with a 19.5 percent reduction in viability after treatment with a targeted therapy, called erlotinib, that is already being used in squamous cell head and neck cancer treatment. Combining the anti-CCR7 antibody and erlotinib, resulted in a 59.5 percent drop in cell survival. The researchers found that both the tumor environment and the tumor cells themselves can produce the ligand that stimulated CCR7 and those tumors that did so were more resistant to standard chemotherapy.

"The results of this study offer additional evidence that this chemokine receptor plays an important role in [squamous cell cancer of the head and neck] progression and in resistance to chemotherapies," the authors write.

This research was published March 25, 2008 in the Journal of the National Cancer Institute.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Inhibition of Chemokine Receptor Activation May Improve Head and Neck Cancer Therapies, Study Suggests." ScienceDaily. ScienceDaily, 26 March 2008. <www.sciencedaily.com/releases/2008/03/080325163809.htm>.
Journal of the National Cancer Institute. (2008, March 26). Inhibition of Chemokine Receptor Activation May Improve Head and Neck Cancer Therapies, Study Suggests. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2008/03/080325163809.htm
Journal of the National Cancer Institute. "Inhibition of Chemokine Receptor Activation May Improve Head and Neck Cancer Therapies, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/03/080325163809.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
Amid Grave Ebola Estimates, US to Test Vaccine

Amid Grave Ebola Estimates, US to Test Vaccine

AP (Aug. 28, 2014) The National Institutes of Health will start the first human safety trials of an experimental Ebola vaccine next week, amid a grave estimate from the World Health Organization that Ebola cases in West Africa could top 20,000. (Aug. 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins