Featured Research

from universities, journals, and other organizations

New Genetic Markers For Crohn's Disease Discovered, Study Suggests

Date:
March 27, 2008
Source:
Johns Hopkins Medical Institutions
Summary:
What is believed to be the largest study of its kind for the genetic roots of inflammatory bowel diseases has suggested new links to Crohn's disease as well as further evidence that some people of Jewish descent are more likely to develop it.

What is believed to be the largest study of its kind for the genetic roots of inflammatory bowel diseases has suggested new links to Crohn's Disease as well as further evidence that some people of Jewish descent are more likely to develop it.

The study examined changes in DNA associated with the two most common forms of inflammatory bowel disease (IBD): Crohn's Disease (CD), which is most frequently marked by inflammation of the final section of the small bowel (ileum) and parts of the colon, and ulcerative colitis (UC), an inflammation of the internal lining of the rectum and colon.

Results of the study, published in this month's edition of Genes and Immunity, included information gleaned from 993 families with IBD, 244 of whom were Ashkenazi Jews. Up to 30 percent of people with IBD in the United States are estimated to have a family history of the condition, and about 25 percent of these families have both CD and UC in the family. People of Ashkenazi Jewish descent are at least twice as likely to develop a form of IBD and are more likely to have familial disease.

"This increased risk for some Jewish people makes our study and results especially significant since this is the first sample size of Jewish families, 244, that was large enough to identify novel gene regions for familial predisposition in this ethnic group," says Johns Hopkins gastroenterologist and genetic investigator Steven R. Brant, M.D., senior author of the study.

By analyzing common DNA variations known as single nucleotide polymorphisms, or SNPs, the team found evidence for genes causing familial Crohn's Disease in the study population specific to Ashkenazi Jewish families with CD on previously identified areas of chromosomes 1 and 3. They also identified a never-before-identified region of chromosome 13 that was shared by both Jewish and non-Jewish families with CD. Evidence for chromosomal regions that may be linked to UC on chromosome 2 and 19 for Jewish and non-Jewish families was also noted, according to Brant.

"What makes these results especially significant is not only the large sample size but also the method we used for screening, namely the use of a high-density, single-nucleotide polymorphism genome-wide linkage process, says Brant." The new process is 10 times faster than older methods at searching the number of variations across the genome, he added.

Up to now, Brant says, no gene regions implicated in IBD were specific to Ashkenazi families, and genetic evidence pointing to why Ashkenazi Jews are twice as likely to get the disorder was lacking. The two genetic regions identified on chromosomes 1 and 3 were specific to Ashkenazi CD and unrelated to known IBD genes.

Although further study is needed to narrow down which specific genes are the major players, Brant says it's already clear that they are in the right "neighborhood" to search for IBD/CD susceptibility genes.

The National Institute of Diabetes and Digestive and Kidney Diseases Inflammatory Bowel Diseases Genetics Consortium (NIDDK-IBDGC) that organized the study is a multi-center team of American and Canadian investigators established in 2002 to examine genetic links among IBD pedigrees.

The subjects were recruited through the six IBD genetic research centers of the NIDDK-IBDGC -- Cedars-Sinai Hospital in Los Angeles, Johns Hopkins Hospital, the University of Chicago, the University of Montreal, the University of Pittsburgh and the University of Toronto.

Genotyping was performed at the SNP Center at the Center for Inherited Disease Research, Baltimore, Md.

The study was funded by the NIDDK, branch of the National Institutes of Health (NIH). Other researchers who worked on this study include lead author Yin Shugart, Ph.D., Johns Hopkins Bloomberg School of Public Health; co-senior author Judy H. Cho, M.D., Yale University School of Medicine, New Haven, Conn. and additional researchers from University of Toronto, Toronto, Canada; University of Pittsburgh, Pittsburgh; Cedar-Sinai Medical Center, Los Angeles; Johns Hopkins University, Baltimore; University of Chicago, Chicago; University of Manitoba, Winnipeg, Manitoba, Canada; University of Sherbrooke Hospital, Fleurimont, Quebec, Canada; McGill University, Montreal, Quebec, Canada and University of Montreal, Quebec, Canada.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "New Genetic Markers For Crohn's Disease Discovered, Study Suggests." ScienceDaily. ScienceDaily, 27 March 2008. <www.sciencedaily.com/releases/2008/03/080326124806.htm>.
Johns Hopkins Medical Institutions. (2008, March 27). New Genetic Markers For Crohn's Disease Discovered, Study Suggests. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/03/080326124806.htm
Johns Hopkins Medical Institutions. "New Genetic Markers For Crohn's Disease Discovered, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/03/080326124806.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins