Featured Research

from universities, journals, and other organizations

Gene Involved In Blood Stem Cell Replication, Movement, Identified

Date:
April 12, 2008
Source:
Joslin Diabetes Center
Summary:
Researchers have identified a gene that is responsible for the division and movement of marrow-derived, blood-forming stem cells, a finding that could have major implications for the future of bone marrow and blood cell transplantation.

Researchers at the Joslin Diabetes Center have identified a gene that is responsible for the division and movement of marrow-derived, blood-forming stem cells, a finding that could have major implications for the future of bone marrow and blood cell transplantation.

Every year, some 45,000 patients undergo bone marrow or peripheral blood progenitor cell transplantation for the treatment of a variety of diseases, including leukemia, lymphoma, and immunodeficiency. Blood cell transplantation may also one day help people with diabetes better tolerate islet cell transplants without the need for prolonged use of powerful immunosuppressive drugs. In addition, transplantation of blood-forming stem cells, also called hematopoietic stem cells, may prove useful in halting the autoimmune process that causes type 1 diabetes.

The success of bone marrow and blood cell transplants depends on the ability of intravenously infused hematopoietic stem cells, which normally reside predominantly in the bone marrow, to accurately and efficiently migrate from the blood to the marrow of the transplant recipient and, once there, to repopulate their pool of mature blood cells.

In studying mice that lack the transcription factor early growth response gene (EGR-1), a team led by Amy Wagers, Ph.D., found that hematopoietic stem cells in the marrow of these animals divided about twice as often as stem cells in mice with the gene. Mice lacking EGR-1 also had higher numbers of such stem cells circulating in their blood.

The paper, published in the April issue of Cell Stem Cell, is the first to identify EGR-1 as a regulator of hematopoietic stem cell migration and proliferation. The transcription factor has already been identified as a tumor suppressor.

"The transcription factor EGR-1 is important in both of these processes," said Wagers, Principal Investigator in the Joslin Section on Developmental and Stem Cell Biology, principal faculty member at the Harvard Stem Cell Institute and Assistant Professor of Pathology at Harvard Medical School. "This factor gives us a handle on the discovery of new pathways that regulate the movement of stem cells."

The knowledge that EGR-1 suppression increases blood-forming stem cell production in the marrow and movement into the bloodstream suggests "a unique opportunity to target this pathway" to manipulate stem cell activity in the context of clinical bone marrow transplantation, the paper says.

"The process of cell migration is critical," Wagers said. Migration of hematopoietic stem cells from the blood to the marrow is essential for effective transplantation, and the reverse process of migration from the marrow to the blood -- an event called "mobilization" -- is increasingly exploited for the collection of donor cells for transplant.

"By figuring out in future studies which genes this transcription factor is regulating we can find new ways, by targeting those genes, to enhance stem cell mobilization in people whose stem cells don't mobilize well," she said.

Bone marrow transplant patients are also vulnerable to infections in the period post-transplant when they may have insufficient numbers of blood cells. A mechanism to speed the recovery of normal levels of circulating blood cells, based on manipulations of EGR-1, would be beneficial in this manner as well, the paper points out.

The Wagers Lab at Joslin focuses on hematopoietic stem cells, which constantly maintain and can fully regenerate the entire blood system, as well as on skeletal muscle satellite cells, involved in skeletal muscle formation. This work is aimed particularly at defining novel mechanisms that regulate the migration, expansion, and regenerative potential of these two distinct adult stem cells.

The research was funded in part by a Burroughs Wellcome Fund career award, Smith Family New Investigator award, and an NIH/NIDDK training grant.

Other authors include Irene M. Min, Ph.D.; Giorgio Pietramaggio, M.D.; Francis S. Kim, all of Joslin; Emmanuelle Passegue, Ph.D., of the University of California, San Francisco; and Kristen E. Stevenson, Dana-Farber Cancer Institute.


Story Source:

The above story is based on materials provided by Joslin Diabetes Center. Note: Materials may be edited for content and length.


Cite This Page:

Joslin Diabetes Center. "Gene Involved In Blood Stem Cell Replication, Movement, Identified." ScienceDaily. ScienceDaily, 12 April 2008. <www.sciencedaily.com/releases/2008/04/080409120629.htm>.
Joslin Diabetes Center. (2008, April 12). Gene Involved In Blood Stem Cell Replication, Movement, Identified. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2008/04/080409120629.htm
Joslin Diabetes Center. "Gene Involved In Blood Stem Cell Replication, Movement, Identified." ScienceDaily. www.sciencedaily.com/releases/2008/04/080409120629.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins