Featured Research

from universities, journals, and other organizations

Acute Kidney Injury With Sepsis: A Unique Pathophysiology

Date:
April 9, 2008
Source:
BioMed Central/Critical Care
Summary:
ICU patients with septic acute kidney injury (AKI) are generally sicker, have a higher burden of illness, a greater risk of mortality and longer stays in hospital than patients with nonseptic AKI. The findings suggest that septic AKI may represent a unique pathophysiologic condition that may require specific detection and clinical interventions.

ICU patients with septic acute kidney injury (AKI) are generally sicker, have a higher burden of illness, a greater risk of mortality and longer stays in hospital than patients with non-septic AKI. The findings suggest that septic AKI may represent a unique pathophysiologic condition that may require specific detection and clinical interventions.

Researchers from Melbourne, Australia, evaluated data on more than 120,000 admissions to 57 intensive care units (ICUs) across Australia. Over 33,000 patients had a diagnosis of sepsis, of which 14,000 (42%) had concomitant AKI (septic AKI). Sepsis accounted for 32.4% of all patients with AKI.

Previous research has found that AKI affects more than one third of all patients admitted to ICUs and that discriminating between the septic and non-septic forms of the condition may have implications for how patients are treated.

Compared to non-septic AKI, patients with septic AKI in this latest study had significantly higher acuity of illness, lower blood pressure, higher heart rates, worse pulmonary function, greater acidemia and higher white cell counts.

The septic condition tended to be more severe, with longer ICU and hospital stays and a higher risk of mortality in hospital.

"Septic AKI is common in the first 24 hours after ICU admission," says Sean Bagshaw, who led the study. "Our findings suggest that septic AKI patients are clinically distinct and have distinguishing features and relevant difference in clinical outcomes when compared to those with non-septic AKI.

"Our study further supports the concept that discriminating septic and non-septic AKI may have clinical importance. We now need to investigate further whether patients may require specific interventions, for example mechanical ventilation or vasopressor support, to reduce injury and promote kidney recovery."

Journal reference: Early Acute Kidney Injury and Sepsis: A Multi-Centre Evaluation. Sean M Bagshaw, Carol George and Rinaldo Bellomo. Critical Care (in press)


Story Source:

The above story is based on materials provided by BioMed Central/Critical Care. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central/Critical Care. "Acute Kidney Injury With Sepsis: A Unique Pathophysiology." ScienceDaily. ScienceDaily, 9 April 2008. <www.sciencedaily.com/releases/2008/04/080409205855.htm>.
BioMed Central/Critical Care. (2008, April 9). Acute Kidney Injury With Sepsis: A Unique Pathophysiology. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2008/04/080409205855.htm
BioMed Central/Critical Care. "Acute Kidney Injury With Sepsis: A Unique Pathophysiology." ScienceDaily. www.sciencedaily.com/releases/2008/04/080409205855.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins