Featured Research

from universities, journals, and other organizations

Acute Kidney Injury With Sepsis: A Unique Pathophysiology

Date:
April 9, 2008
Source:
BioMed Central/Critical Care
Summary:
ICU patients with septic acute kidney injury (AKI) are generally sicker, have a higher burden of illness, a greater risk of mortality and longer stays in hospital than patients with nonseptic AKI. The findings suggest that septic AKI may represent a unique pathophysiologic condition that may require specific detection and clinical interventions.

ICU patients with septic acute kidney injury (AKI) are generally sicker, have a higher burden of illness, a greater risk of mortality and longer stays in hospital than patients with non-septic AKI. The findings suggest that septic AKI may represent a unique pathophysiologic condition that may require specific detection and clinical interventions.

Related Articles


Researchers from Melbourne, Australia, evaluated data on more than 120,000 admissions to 57 intensive care units (ICUs) across Australia. Over 33,000 patients had a diagnosis of sepsis, of which 14,000 (42%) had concomitant AKI (septic AKI). Sepsis accounted for 32.4% of all patients with AKI.

Previous research has found that AKI affects more than one third of all patients admitted to ICUs and that discriminating between the septic and non-septic forms of the condition may have implications for how patients are treated.

Compared to non-septic AKI, patients with septic AKI in this latest study had significantly higher acuity of illness, lower blood pressure, higher heart rates, worse pulmonary function, greater acidemia and higher white cell counts.

The septic condition tended to be more severe, with longer ICU and hospital stays and a higher risk of mortality in hospital.

"Septic AKI is common in the first 24 hours after ICU admission," says Sean Bagshaw, who led the study. "Our findings suggest that septic AKI patients are clinically distinct and have distinguishing features and relevant difference in clinical outcomes when compared to those with non-septic AKI.

"Our study further supports the concept that discriminating septic and non-septic AKI may have clinical importance. We now need to investigate further whether patients may require specific interventions, for example mechanical ventilation or vasopressor support, to reduce injury and promote kidney recovery."

Journal reference: Early Acute Kidney Injury and Sepsis: A Multi-Centre Evaluation. Sean M Bagshaw, Carol George and Rinaldo Bellomo. Critical Care (in press)


Story Source:

The above story is based on materials provided by BioMed Central/Critical Care. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central/Critical Care. "Acute Kidney Injury With Sepsis: A Unique Pathophysiology." ScienceDaily. ScienceDaily, 9 April 2008. <www.sciencedaily.com/releases/2008/04/080409205855.htm>.
BioMed Central/Critical Care. (2008, April 9). Acute Kidney Injury With Sepsis: A Unique Pathophysiology. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2008/04/080409205855.htm
BioMed Central/Critical Care. "Acute Kidney Injury With Sepsis: A Unique Pathophysiology." ScienceDaily. www.sciencedaily.com/releases/2008/04/080409205855.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins