Featured Research

from universities, journals, and other organizations

Low-Molecular-Weight Heparins Inhibit Tumor Growth, Study Shows

Date:
April 15, 2008
Source:
Roswell Park Cancer Institute
Summary:
Low-molecular-weight heparins block the formation of new blood vessels and prevent tumor growth, according to the results of a study. Angiogenesis -- the development of new blood vessels -- fuels cancer cell reproduction. The use of low-molecular-weight heparins (LMWHs) has been shown to extend survival in cancer patients by reducing the clotting action of blood. However, the mechanism is unclear.

Low-molecular-weight heparins block the formation of new blood vessels and prevent tumor growth, according to the results of a study by Michael Wong, MD, PhD, FRCPC, Department of Medicine, Roswell Park Cancer Institute (RPCI).

Related Articles


Angiogenesis − the development of new blood vessels − fuels cancer cell reproduction. The use of low-molecular-weight heparins (LMWHs) has been shown to extend survival in cancer patients by reducing the clotting action of blood. However, the mechanism is unclear.

This study tested the hypothesis that sequestering blood vessel growth factors, such as fibroblast growth factor (FGF), would interfere with angiogenesis and lead to tumor cell death. The hypothesis was tested in a model group of a highly vascularized tumors treated with varying amounts of heparin and LMWH and compared with a model group that was untreated.

Researchers report that LMWHs interfered with the signaling in the blood vessel growth pathway and significantly inhibited the growth of highly vascular tumors. This was in contrast to the non-treated model, which exhibited a large number of blood vessels and a well-constructed vasculature.

“This study indicated that low-molecular-weight heparins strip and sequester a blood vessel growth factor, in this case FGF, away from its receptor and reduce vascular tumor growth,” said Dr. Wong. “Heparins are already in clinical use and by elucidating the antitumor effects, we hope to have an immediate beneficial impact on cancer patients.”

The abstract  “Low-molecular-weight heparins (LMWHs) inhibit tumor growth through the sequestration of angiogenic cytokines” was presented on April 13 at at the 2008 annual meeting of the American Association for Cancer Research in San Diego, CA.


Story Source:

The above story is based on materials provided by Roswell Park Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Roswell Park Cancer Institute. "Low-Molecular-Weight Heparins Inhibit Tumor Growth, Study Shows." ScienceDaily. ScienceDaily, 15 April 2008. <www.sciencedaily.com/releases/2008/04/080414212841.htm>.
Roswell Park Cancer Institute. (2008, April 15). Low-Molecular-Weight Heparins Inhibit Tumor Growth, Study Shows. ScienceDaily. Retrieved November 29, 2014 from www.sciencedaily.com/releases/2008/04/080414212841.htm
Roswell Park Cancer Institute. "Low-Molecular-Weight Heparins Inhibit Tumor Growth, Study Shows." ScienceDaily. www.sciencedaily.com/releases/2008/04/080414212841.htm (accessed November 29, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins