Featured Research

from universities, journals, and other organizations

Low-Molecular-Weight Heparins Inhibit Tumor Growth, Study Shows

Date:
April 15, 2008
Source:
Roswell Park Cancer Institute
Summary:
Low-molecular-weight heparins block the formation of new blood vessels and prevent tumor growth, according to the results of a study. Angiogenesis -- the development of new blood vessels -- fuels cancer cell reproduction. The use of low-molecular-weight heparins (LMWHs) has been shown to extend survival in cancer patients by reducing the clotting action of blood. However, the mechanism is unclear.

Low-molecular-weight heparins block the formation of new blood vessels and prevent tumor growth, according to the results of a study by Michael Wong, MD, PhD, FRCPC, Department of Medicine, Roswell Park Cancer Institute (RPCI).

Related Articles


Angiogenesis − the development of new blood vessels − fuels cancer cell reproduction. The use of low-molecular-weight heparins (LMWHs) has been shown to extend survival in cancer patients by reducing the clotting action of blood. However, the mechanism is unclear.

This study tested the hypothesis that sequestering blood vessel growth factors, such as fibroblast growth factor (FGF), would interfere with angiogenesis and lead to tumor cell death. The hypothesis was tested in a model group of a highly vascularized tumors treated with varying amounts of heparin and LMWH and compared with a model group that was untreated.

Researchers report that LMWHs interfered with the signaling in the blood vessel growth pathway and significantly inhibited the growth of highly vascular tumors. This was in contrast to the non-treated model, which exhibited a large number of blood vessels and a well-constructed vasculature.

“This study indicated that low-molecular-weight heparins strip and sequester a blood vessel growth factor, in this case FGF, away from its receptor and reduce vascular tumor growth,” said Dr. Wong. “Heparins are already in clinical use and by elucidating the antitumor effects, we hope to have an immediate beneficial impact on cancer patients.”

The abstract  “Low-molecular-weight heparins (LMWHs) inhibit tumor growth through the sequestration of angiogenic cytokines” was presented on April 13 at at the 2008 annual meeting of the American Association for Cancer Research in San Diego, CA.


Story Source:

The above story is based on materials provided by Roswell Park Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Roswell Park Cancer Institute. "Low-Molecular-Weight Heparins Inhibit Tumor Growth, Study Shows." ScienceDaily. ScienceDaily, 15 April 2008. <www.sciencedaily.com/releases/2008/04/080414212841.htm>.
Roswell Park Cancer Institute. (2008, April 15). Low-Molecular-Weight Heparins Inhibit Tumor Growth, Study Shows. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2008/04/080414212841.htm
Roswell Park Cancer Institute. "Low-Molecular-Weight Heparins Inhibit Tumor Growth, Study Shows." ScienceDaily. www.sciencedaily.com/releases/2008/04/080414212841.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins