Featured Research

from universities, journals, and other organizations

Mutation In Human Gene Helps Protect Against Fatal Malaria

Date:
April 22, 2008
Source:
University of Toronto
Summary:
New research suggests that not everyone who is bitten by a malaria-infected mosquito develops life threatening health problems. Malaria causes an estimated 500 million clinical cases worldwide with symptoms ranging from headache, high fevers and nausea to more than 1 million deaths annually.

New research suggests that not everyone who is bitten by a malaria-infected mosquito develops life threatening health problems according to scientists at the University of Toronto.

Related Articles


Malaria causes an estimated 500 million clinical cases worldwide with symptoms ranging from headache, high fevers and nausea to more than 1 million deaths annually.

"Malaria has had a major effect on the evolution of our species. Mutations occurring in our genome that have helped us survive malaria have been selected for over tens of 1,000s of years of co-existing with this parasite. Understanding how these mutations make us more resistant to malaria can help us design innovative new strategies to prevent or treat severe malaria in places such as sub-Saharan Africa," says researcher Kevin Kain, a Professor out of the Department of Medicine at U of T and one of the lead researchers on the project. "Our research shows that people who have an enzyme deficiency or those who carry the gene trait for this deficiency may be protected from severe and fatal malaria."

The team headed by Dr. Kain and which included researchers from McGill University found that a deficiency in an enzyme called pyruvate kinase, which is required for energy production in the body, provides protection against malaria infection.

The findings could lead to the design of new novel therapies to treat and prevent severe and fatal malaria through enhancing the body's protective pathways instead of inundating the body with drugs. The study was funded by the Canadian Institutes of Health Research (CIHR) Team grant in malaria.

The study findings were published in the April 24th issue of New England Journal of Medicine.


Story Source:

The above story is based on materials provided by University of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University of Toronto. "Mutation In Human Gene Helps Protect Against Fatal Malaria." ScienceDaily. ScienceDaily, 22 April 2008. <www.sciencedaily.com/releases/2008/04/080421114612.htm>.
University of Toronto. (2008, April 22). Mutation In Human Gene Helps Protect Against Fatal Malaria. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2008/04/080421114612.htm
University of Toronto. "Mutation In Human Gene Helps Protect Against Fatal Malaria." ScienceDaily. www.sciencedaily.com/releases/2008/04/080421114612.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins