Featured Research

from universities, journals, and other organizations

Breast Cancer Subtypes Originate From Different Biological Pathways

Date:
April 28, 2008
Source:
Public Library of Science
Summary:
There is a biological distinction between breast cancers that depend on hormones and cancers that do not, according to new research. Scientists previously thought that hormone dependent breast cancers, which usually require treatment with surgery and anti-hormone drugs, originated from the same biological pathway as hormone independent breast cancers, which are treated with surgery and chemotherapy.

There is a biological distinction between breast cancers that depend on hormones and those that do not, according to new research.

Scientists previously thought that hormone dependent breast cancers, which usually require treatment with surgery and anti-hormone drugs, originated from the same biological pathway as hormone independent breast cancers, which are treated with surgery and chemotherapy.

In the largest study of its kind, an international consortium of cancer researchers studied the genetic makeup of over 23,000 breast cancer cases.*

Dr. Paul Pharoah, lead author based at the University of Cambridge, said: "We looked at five genetic variants associated with breast cancer to see if they were more likely to be found in hormone dependent or independent breast cancers. One common genetic variant, FGFR2, was strongly associated with hormone dependent breast cancer, but weakly associated with hormone independent cancer. This shows that they have distinct genetic origins, and are different diseases."

Dr Lesley Walker, Cancer Research UK's director of cancer information, said: "Scientists were previously unsure how different types of breast cancer developed. Although the findings won't have any immediate effects on the treatment of women with the disease, they are important in helping to define the next steps in our research on the causes of this major cancer."

This discovery provides strong evidence that the subtypes originate from separate pathways and could guide future research into prevention and treatments for the cancer types as different diseases. This study was funded by Cancer Research UK.

* The researchers in this study used data provided by the Breast Cancer Association Consortium (BCAC) -- a huge international collaborative group of researchers interested in inherited risk of breast cancer. Co-ordination of BCAC is funded by Cancer Research UK.

Hormone dependent breast cancers are also known as ER positive and hormone independent breast cancers as ER negative.

Journal reference: Garcia-Closas M, Hall P, Nevanlinna H, Pooley K, Morrison J, et al. (2008) Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics. PLoS Genet 4(4): e1000054. doi:10.1371/journal.pgen.1000054


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Breast Cancer Subtypes Originate From Different Biological Pathways." ScienceDaily. ScienceDaily, 28 April 2008. <www.sciencedaily.com/releases/2008/04/080425065414.htm>.
Public Library of Science. (2008, April 28). Breast Cancer Subtypes Originate From Different Biological Pathways. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2008/04/080425065414.htm
Public Library of Science. "Breast Cancer Subtypes Originate From Different Biological Pathways." ScienceDaily. www.sciencedaily.com/releases/2008/04/080425065414.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins