Featured Research

from universities, journals, and other organizations

Breast Cancer Subtypes Originate From Different Biological Pathways

Date:
April 28, 2008
Source:
Public Library of Science
Summary:
There is a biological distinction between breast cancers that depend on hormones and cancers that do not, according to new research. Scientists previously thought that hormone dependent breast cancers, which usually require treatment with surgery and anti-hormone drugs, originated from the same biological pathway as hormone independent breast cancers, which are treated with surgery and chemotherapy.

There is a biological distinction between breast cancers that depend on hormones and those that do not, according to new research.

Scientists previously thought that hormone dependent breast cancers, which usually require treatment with surgery and anti-hormone drugs, originated from the same biological pathway as hormone independent breast cancers, which are treated with surgery and chemotherapy.

In the largest study of its kind, an international consortium of cancer researchers studied the genetic makeup of over 23,000 breast cancer cases.*

Dr. Paul Pharoah, lead author based at the University of Cambridge, said: "We looked at five genetic variants associated with breast cancer to see if they were more likely to be found in hormone dependent or independent breast cancers. One common genetic variant, FGFR2, was strongly associated with hormone dependent breast cancer, but weakly associated with hormone independent cancer. This shows that they have distinct genetic origins, and are different diseases."

Dr Lesley Walker, Cancer Research UK's director of cancer information, said: "Scientists were previously unsure how different types of breast cancer developed. Although the findings won't have any immediate effects on the treatment of women with the disease, they are important in helping to define the next steps in our research on the causes of this major cancer."

This discovery provides strong evidence that the subtypes originate from separate pathways and could guide future research into prevention and treatments for the cancer types as different diseases. This study was funded by Cancer Research UK.

* The researchers in this study used data provided by the Breast Cancer Association Consortium (BCAC) -- a huge international collaborative group of researchers interested in inherited risk of breast cancer. Co-ordination of BCAC is funded by Cancer Research UK.

Hormone dependent breast cancers are also known as ER positive and hormone independent breast cancers as ER negative.

Journal reference: Garcia-Closas M, Hall P, Nevanlinna H, Pooley K, Morrison J, et al. (2008) Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics. PLoS Genet 4(4): e1000054. doi:10.1371/journal.pgen.1000054


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Breast Cancer Subtypes Originate From Different Biological Pathways." ScienceDaily. ScienceDaily, 28 April 2008. <www.sciencedaily.com/releases/2008/04/080425065414.htm>.
Public Library of Science. (2008, April 28). Breast Cancer Subtypes Originate From Different Biological Pathways. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2008/04/080425065414.htm
Public Library of Science. "Breast Cancer Subtypes Originate From Different Biological Pathways." ScienceDaily. www.sciencedaily.com/releases/2008/04/080425065414.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com
Radio Waves Knock out Knee Pain

Radio Waves Knock out Knee Pain

Ivanhoe (Aug. 27, 2014) Doctors have used radio frequency ablation or RFA to reduce neck and back pain for years. But now, that same technique is providing longer-term relief for patients with severe knee pain. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins