Featured Research

from universities, journals, and other organizations

Daycare Attendance Early In Life Cuts Childhood Leukemia Risk By 30 Percent, Analysis Finds

Date:
April 28, 2008
Source:
Children With Leukaemia
Summary:
Children who attend day care or play groups have about a 30% lower risk of developing the most common type of childhood leukemia than those who do not, according to a new analysis of studies investigating the link. The research is the first comprehensive analysis of studies investigating the association between social contact and childhood leukemia.

Children who attend day care or play groups have about a 30% lower risk of developing the most common type of childhood leukaemia than those who do not, according to a new analysis of studies investigating the link.

Related Articles


The new research, to be presented April 29 at the 2nd Children with Leukaemia Causes and Prevention of Childhood Leukaemia Conference in London, is the first comprehensive analysis of studies investigating the association between social contact and childhood leukaemia.

"Combining the results from these studies together provided us with more confidence that the protective effect is real. Analysing the evidence in this way gives a more reliable answer to the question and a more precise estimate of the magnitude of the effect," said the study's leader, Dr. Patricia Buffler, professor of epidemiology at the School of Public Health of the University of California, Berkeley.

While the analysis does not reveal how intense social contact might ward off childhood leukaemia, it bolsters the theory that children exposed to common infections early in life gain protection from the disease. It is known that environments such as day care centres increase the chance of infections spreading. Some proponents of the theory believe that if the immune system is not challenged early in life and does not develop normally it may mount an inappropriate response to infections encountered later in childhood and that this could provoke the development of leukaemia.

Leukaemia is the most common cancer found in children in the industrialised world, affecting about one in 2,000 children. Incidence of the disease has been on the increase for decades. Acute lymphoblastic leukaemia, or ALL, the type of leukaemia the studies focused on, accounts for more than 80% of cases and most often occurs in children aged between 2 and 5 years. Scientists believe that for most types of childhood leukaemia to develop, there first must be a genetic mutation in the womb, followed by a second trigger during childhood that results in 1% of those children developing the disease. Infection -- or the timing of infection - is one of the suspected triggers.

Buffler's analysis included 14 published studies comprising a total of 6,108 children with leukaemia and 13,704 without the disease. Parents were asked about day care and playgroup attendance, as well as other forms of social interaction with other children. The studies varied in the timing, duration and extent of social contact investigated and in the age groups and types of leukaemia studied. Twelve of the studies found some indication of a protective effect of social interaction with other children, while two found no effect. No study found that social contact increased the risk of childhood leukaemia.

"Our analysis concluded that children who attended day care or play groups had about a 30% lower risk of developing leukaemia than those who did not. Combined results for studies of day care attendance specifically before the age of 1 or 2 showed a similarly reduced risk," Buffler said.

The protective effect became even stronger when the researchers omitted from the analysis 5 studies in which the selection of healthy children for the comparison group relied on methods not considered optimal. In that analysis, children exposed to social contact were almost 40% less likely to go on to develop leukaemia than their counterparts.

In a separate report presented at the same conference on the same day, scientists reviewed the evidence from studies that have investigated a link between infection and childhood leukaemia. They examined not only the idea that early life infections protect against the disease but also whether vaccination plays a role. In addition, they examined two other related areas of research: the role of infection during pregnancy and whether infection might be a factor influencing childhood leukaemia risk in situations where the population mix changes.

The report concluded that the evidence regarding whether infection during pregnancy or in situations of unusual patterns of population mixing influences the risk is inconclusive at present and that further research is necessary.

"On the question of whether infection early in life protects against leukaemia, the best evidence comes from studies of indirect measures of infection - which eliminates many of the problems common in trying to study infections directly - as well as from studies on immune system stimulation and on the genetics of immune responses," said one of the report's authors, Dr. Adrienne Morgan, staff scientist at Children  with Leukaemia.

"Putting our review together with the new analysis on social interaction, we can say pretty confidently that childcare, breastfeeding and vaccination are good things. This gives a steer to the biologists looking for what mechanisms might be at play," she said.


Story Source:

The above story is based on materials provided by Children With Leukaemia. Note: Materials may be edited for content and length.


Cite This Page:

Children With Leukaemia. "Daycare Attendance Early In Life Cuts Childhood Leukemia Risk By 30 Percent, Analysis Finds." ScienceDaily. ScienceDaily, 28 April 2008. <www.sciencedaily.com/releases/2008/04/080428084232.htm>.
Children With Leukaemia. (2008, April 28). Daycare Attendance Early In Life Cuts Childhood Leukemia Risk By 30 Percent, Analysis Finds. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2008/04/080428084232.htm
Children With Leukaemia. "Daycare Attendance Early In Life Cuts Childhood Leukemia Risk By 30 Percent, Analysis Finds." ScienceDaily. www.sciencedaily.com/releases/2008/04/080428084232.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins