Featured Research

from universities, journals, and other organizations

Stem Cell-Like Cancer Cells Resistant To Standard Therapy, Responsive To Targeted Therapy

Date:
April 30, 2008
Source:
Journal of the National Cancer Institute
Summary:
A comparison of breast cancer biopsies before and after treatment show that a subset of cells, which have stem cell-like properties, are resistant to standard chemotherapy. Tumors treated with lapatinib, which inhibits a pathway important for self-renewal, retained a smaller fraction of these tumorigenic cells after therapy.

A comparison of breast cancer biopsies before and after treatment show that a subset of cells, which have stem cell-like properties, are resistant to standard chemotherapy. Tumors treated with lapatinib, which inhibits a pathway important for self-renewal, retained a smaller fraction of these tumorigenic cells after therapy.

Several research groups have identified a subset of cells in breast tumors that have the ability to form colonies in culture and give rise to tumors in mouse models. These cells, which express CD44 protein on their surface but little or no CD24 (CD44+/CD24-/low), are frequently referred to as cancer stem cells and may be resistant to standard chemotherapeutic agents. Lapatinib, which is approved for treatment of HER2-positive breast cancer, inhibits the HER2 pathway. The drug also inhibits the epidermal growth factor receptor pathway, which may be important for stem cell proliferation.

To find out how the CD44+/CD24-/low cells respond to cytotoxic chemotherapy, Jenny Chang, M.D., from the Baylor College of Medicine in Houston and colleagues compared breast cancer biopsy samples taken from patients before and after standard chemotherapy or lapatinib therapy.

After chemotherapy, the fraction of CD44+/CD24-/low cells increased in 31 paired biopsy samples, from a mean of 4.7 percent at baseline to 13.6 percent after 12 weeks of therapy. Biopsy samples taken after chemotherapy were also more efficient at forming mammospheres, an indication of self-renewal, when grown in culture. By contrast, there was a decrease in the proportion of CD44+/CD24-/low cells in biopsies from 21 women treated with lapatinib, from 10 percent to 7.5 percent.

"Results of this study are encouraging and suggest that inhibition of key regulatory pathways responsible for self-renewal could augment the effects of conventional therapy and improve clinical outcome," the authors write.

This research was reported April 29 in the Journal of the National Cancer Institute.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Stem Cell-Like Cancer Cells Resistant To Standard Therapy, Responsive To Targeted Therapy." ScienceDaily. ScienceDaily, 30 April 2008. <www.sciencedaily.com/releases/2008/04/080429170436.htm>.
Journal of the National Cancer Institute. (2008, April 30). Stem Cell-Like Cancer Cells Resistant To Standard Therapy, Responsive To Targeted Therapy. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/04/080429170436.htm
Journal of the National Cancer Institute. "Stem Cell-Like Cancer Cells Resistant To Standard Therapy, Responsive To Targeted Therapy." ScienceDaily. www.sciencedaily.com/releases/2008/04/080429170436.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins