Featured Research

from universities, journals, and other organizations

Gastric Juice For Diagnosis Of H. Pylori Infection In Patients On Proton Pump Inhibitors

Date:
April 30, 2008
Source:
World Journal of Gastroenterology
Summary:
Scientists have determined that a gastric juice polymerase chain reaction test for the diagnosis of Helicobacter pylori infection has greater sensitivity compared to histology when commonly used potent acid-reducing drugs such as proton pump inhibitors are being used. The use of the gastric juice PCR test can be recommended to confirm H. pylori status in patients taking PPIs.

This research study led by Dr. Javed Yakoob from Aga Khan University, Karachi, has determined that a gastric juice polymerase chain reaction test for the diagnosis of Helicobacter pylori infection has greater sensitivity compared to histology when commonly used potent acid-reducing drugs such as proton pump inhibitors are being used. The use of the gastric juice PCR test can be recommended to confirm H. pylori status in patients taking PPIs.

Related Articles


This study determined the efficiency of a gastric juice PCR test for the detection of H. pylori infection in patients receiving PPI therapy and compared it with histology and gastric biopsy PCR.

Helicobacter pylori (H pylori) is a gram-negative spiral bacterium that infects the human gastric mucosa and is associated with gastritis, gastroduodenal ulcer disease, gastric carcinoma, and lymphoma of mucosa-associated lymphoid tissue.

An accurate diagnosis of H pylori infection is important when seeking to cure patients with persistent gastric symptoms in which H pylori infection is suspected. In patients on acid-reducing drugs such as PPI or H2-receptor blockers (H2RB), the accuracy of the rapid urease test, urea breath test and histology are known to be lower for the diagnosis of H pylori infection.

In the view of the authors, the development of new targets to test for H pylori infection in patients with prior use of acid-reducing drugs is important, considering the morbidity and mortality associated with this infection. Gastric juice PCR has been evaluated as a highly specific and rapid method for the detection of H pylori.

Using an original design, this study represents a real and valuable advance in the methodology of diagnosis in this field. This research was performed by doctors with the Department of Microbiology and Pathology, Faculty of Health Sciences, at Aga Khan University in Karachi, Pakistan. The study was funded by the Aga Khan University Research Committee.

Reference: Yakoob J, Rasool S, Abbas Z, Jafri W, Abid S, Islam M, Ahmad Z. Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitors. World J Gastroenterol 2008; 14(10): 1539-1543 http://www.wjgnet.com/1007-9327/14/1539.asp


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Cite This Page:

World Journal of Gastroenterology. "Gastric Juice For Diagnosis Of H. Pylori Infection In Patients On Proton Pump Inhibitors." ScienceDaily. ScienceDaily, 30 April 2008. <www.sciencedaily.com/releases/2008/04/080430093353.htm>.
World Journal of Gastroenterology. (2008, April 30). Gastric Juice For Diagnosis Of H. Pylori Infection In Patients On Proton Pump Inhibitors. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2008/04/080430093353.htm
World Journal of Gastroenterology. "Gastric Juice For Diagnosis Of H. Pylori Infection In Patients On Proton Pump Inhibitors." ScienceDaily. www.sciencedaily.com/releases/2008/04/080430093353.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins