Featured Research

from universities, journals, and other organizations

Gene Function In Regulating Body Size Helps Inform Novel Cancer Treatments

Date:
May 13, 2008
Source:
Sunnybrook Health Sciences Centre
Summary:
In a leading study that has implications for the development of novel therapies for a number of breast, lung and ovarian cancers that have lost the expression of a gene called glypican-3, researchers have discovered how the loss of the GPC3 gene induces overgrowth through certain growth factors such as Sonic Hedgehog which stimulate cancer growth.

In a leading study that has implications for the development of novel therapies for a number of breast, lung and ovarian cancers that have lost the expression of a gene called glypican-3 (GPC3), Sunnybrook researchers have discovered how the loss of the GPC3 gene induces overgrowth through certain growth factors such as Sonic Hedgehog which stimulate cancer growth.

Published May 12 in Developmental Cell, the study examines the molecular mechanism by which lack of functional GPC3 causes overgrowth in the Simpson-Golabi-Behmel syndrome (SGBS), a rare disorder that predisposes to cancers.

"This vital new finding at the molecular level opens doors for the development of novel treatments to inhibit overgrowth activity to benefit SGBS patients and the many breast, lung and ovarian cancer patients linked to loss of GPC3," says Dr. Jorge Filmus, senior scientist, Division of Molecular and Cellular Biology, Sunnybrook Research Institute, and the study's lead investigator. Early clinical trials presented at the last annual meeting of the American Association for Cancer Research in which cancer patients are being treated using Hedgehog-inhibitor drugs show promise.

GPC3 or glypican-3 is one of six genes of the glypican family. Glypicans are expressed predominantly during development in a stage and tissue specific manner suggesting they play a role in cell growth and in establishing the shape of tissues and organs.

This research was supported by the Canadian Institutes of Health Research and the National Cancer Institute of Canada.


Story Source:

The above story is based on materials provided by Sunnybrook Health Sciences Centre. Note: Materials may be edited for content and length.


Cite This Page:

Sunnybrook Health Sciences Centre. "Gene Function In Regulating Body Size Helps Inform Novel Cancer Treatments." ScienceDaily. ScienceDaily, 13 May 2008. <www.sciencedaily.com/releases/2008/05/080512163831.htm>.
Sunnybrook Health Sciences Centre. (2008, May 13). Gene Function In Regulating Body Size Helps Inform Novel Cancer Treatments. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2008/05/080512163831.htm
Sunnybrook Health Sciences Centre. "Gene Function In Regulating Body Size Helps Inform Novel Cancer Treatments." ScienceDaily. www.sciencedaily.com/releases/2008/05/080512163831.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins