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Low Cholesterol Leads To Lower PSA, Lower Prostate Cancer Risk, Study Suggests

Date:
May 18, 2008
Source:
American Urological Association
Summary:
Managing your cholesterol may also help you manage your prostate- specific antigen level. New data explores the relationship between low-density lipoprotein (LDL) cholesterol and PSA prior to beginning statin therapy.

Managing your cholesterol may also help you manage your prostate- specific antigen (PSA) level. Data presented at the 103rd Annual Scientific Meeting of the American Urological Association explored the relationship between low-density lipoprotein (LDL) cholesterol and PSA prior to beginning statin therapy.

Data collected from a study of 1,214 men prescribed cholesterol-lowering drugs (statins) between 1990 and 2006 at the Durham Veteran Affairs Medical Center in North Carolina shows that PSA levels were reduced after starting statin medications and that this decline was proportional to the decline in LDL cholesterol.

In 2007, a retrospective study showed that men taking statins to lower their cholesterol also experienced a proportional decline in their PSA levels. This new study confirms that evidence and highlights the fact that cholesterol may play a role in prostate cancer development and progression.

Data was collected from men who were free of prostate cancer, had not undergone prostate surgery or taken medicine to alter androgen levels, and whose PSA was between 0.1 and 10.0 ng/ml. The outcome of this study, if confirmed by additional research, could provide further evidence for the role cholesterol plays in prostate biology.

The results of this study indicate that cholesterol and PSA are valuable indicators of overall health for men and should continue to be monitored together. It remains to be seen whether or not lowering your PSA through statin medications could potentially mask the presence of prostate disease.


Story Source:

The above story is based on materials provided by American Urological Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hamilton RJ, Platz EA, Goldberg KC, Freedland SJ: The association between cholesterol and PSA. J Urol, suppl., 2008; 179: 721, abstract 2094. [link]

Cite This Page:

American Urological Association. "Low Cholesterol Leads To Lower PSA, Lower Prostate Cancer Risk, Study Suggests." ScienceDaily. ScienceDaily, 18 May 2008. <www.sciencedaily.com/releases/2008/05/080515072654.htm>.
American Urological Association. (2008, May 18). Low Cholesterol Leads To Lower PSA, Lower Prostate Cancer Risk, Study Suggests. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2008/05/080515072654.htm
American Urological Association. "Low Cholesterol Leads To Lower PSA, Lower Prostate Cancer Risk, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/05/080515072654.htm (accessed September 21, 2014).

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