Featured Research

from universities, journals, and other organizations

Incontinence Treatment: Muscle-derived Stem Cells Prove Effective In Reparing Sphincter Damage To Restore Continence

Date:
May 17, 2008
Source:
American Urological Association
Summary:
Transplantation of muscle-derived stem cells may provide a safe and effective treatment for patients suffering from urinary incontinence following a surgical procedure. Patients with incontinence resulting from iatrogenic sphincter damage may benefit from this therapy.

Transplantation of muscle-derived stem cells may provide a safe and effective treatment for patients suffering from urinary incontinence following a surgical procedure. Two studies presented at the 103rd Annual Scientific Meeting of the American Urological Association (AUA), show that patients with incontinence resulting from iatrogenic sphincter damage may benefit from this therapy. Researchers are from Germany and Austria.

Related Articles


Certain medical procedures, including transurethral resection of the prostate and radical prostatectomy can result in damage to the external urinary sphincter. In one study, a German research team successfully implanted muscle cells grown from tissue from the patients’ deltoid muscles into the damaged sphincter.

One year later, four patients were completely continent and 19 patients had improved from grade III to grade I incontinence. With more than half of the patients experiencing an improvement in continence after four months, the use of muscle-derived cells to repair sphincter damage proved successful. Minor side effects were observed in five patients.

A second study reaffirmed these findings. Using muscle cells from the upper arms of 65 incontinent men who had undergone a prostatectomy, researchers in Austria grew the cells in a laboratory and then implanted them. Patients were evaluated before the surgery to define their level of incontinence and evaluated post-operatively to monitor complications.

Prior to therapy, the mean number of pads used per day was 4.89, and after treatment, the mean number of pads decreased to 1.59. 27.9 percent of patients did not wear pads at all and 43.6 percent reported that they only required a pad for “special occasions.” Only 28.5 percent of patients still required pads.


Story Source:

The above story is based on materials provided by American Urological Association. Note: Materials may be edited for content and length.


Journal References:

  1. Otto T, Eimer C, Gerullis H: Repair of iatrogenic sphincter damage and urinary incontinence by autologous skeletal muscle derived http://dx.doi.org/10.1016/S0022-5347(08)61422-6cells (MDC). J Urol, suppl., 2008; 179: 484, abstract 1414. [link]
  2. Strasser H, Mitterberger M, Dalpiaz O, Kerschbaumer A, Pinggera GM, Frauscher F et al: Transurethral ultrasound guided injection of autologous myo- and fibroblasts in treatment of incontinence in men: 2 year data. J Urol, suppl., 2008; 179: 483, abstract 1413. [link]

Cite This Page:

American Urological Association. "Incontinence Treatment: Muscle-derived Stem Cells Prove Effective In Reparing Sphincter Damage To Restore Continence." ScienceDaily. ScienceDaily, 17 May 2008. <www.sciencedaily.com/releases/2008/05/080515072735.htm>.
American Urological Association. (2008, May 17). Incontinence Treatment: Muscle-derived Stem Cells Prove Effective In Reparing Sphincter Damage To Restore Continence. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2008/05/080515072735.htm
American Urological Association. "Incontinence Treatment: Muscle-derived Stem Cells Prove Effective In Reparing Sphincter Damage To Restore Continence." ScienceDaily. www.sciencedaily.com/releases/2008/05/080515072735.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins