Featured Research

from universities, journals, and other organizations

Nanotechnology In Reverse Uses Red Blood Cell To Calibrate Atomic Force Microscope

Date:
May 16, 2008
Source:
University of California - Davis
Summary:
Nanotechnology researchers have shown that they can use a red blood cell to calibrate a sensitive instrument, an atomic force microscope. An atomic force microscope uses a tiny lever that runs over the surface of an object. Small deflections of the tip are read and translated to produce an image of the object's surface. However, accurate calibration of the springiness of the tip is difficult.

Nanotechnology researchers at UC Davis have shown that they can use a red blood cell to calibrate a sensitive instrument, an atomic force microscope.

Related Articles


"It turns around the rules of nanotechnology, by using biology to calibrate an instrument," said Volkmar Heinrich, assistant professor in the Department of Biomedical Engineering at UC Davis and co-author of the paper with graduate student Chawin Ounkomol.

An atomic force microscope uses a tiny lever that runs over the surface of an object. Small deflections of the tip are read and translated to produce an image of the object's surface. However, accurate calibration of the springiness of the tip is difficult.

Heinrich and Ounkomol used individual red blood cells sucked onto the end of a pipette to push the lever. The lab has previously developed a model that calculates the exact forces needed to squeeze a red blood cell by a certain amount. They could therefore use the red blood cell to very accurately calibrate the springiness of the atomic force microscope cantilever.

Heinrich does not see the technique as a new way to calibrate these instruments, but it does show that the red blood cell can be used as an accurate force transducer, he said, and could be used as a tool to measure forces between individual molecules and cells or between molecules. Those measurements can advance our understanding of cell biology, for example how cancers spread or how immune cells enter tissues to fight infection.

The paper is published in the April 14 issue of the journal Applied Physics Letters and also was selected for the April 28 issue of the Virtual Journal of Nanoscale Science and Technology.


Story Source:

The above story is based on materials provided by University of California - Davis. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Davis. "Nanotechnology In Reverse Uses Red Blood Cell To Calibrate Atomic Force Microscope." ScienceDaily. ScienceDaily, 16 May 2008. <www.sciencedaily.com/releases/2008/05/080515092622.htm>.
University of California - Davis. (2008, May 16). Nanotechnology In Reverse Uses Red Blood Cell To Calibrate Atomic Force Microscope. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2008/05/080515092622.htm
University of California - Davis. "Nanotechnology In Reverse Uses Red Blood Cell To Calibrate Atomic Force Microscope." ScienceDaily. www.sciencedaily.com/releases/2008/05/080515092622.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Matter & Energy News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cablevision Enters Wi-Fi Phone Fray

Cablevision Enters Wi-Fi Phone Fray

Reuters - Business Video Online (Jan. 26, 2015) The entry by Cablevision and Google could intensify the already heated price wars for mobile phone service. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Hector the Robot Mimics a Giant Stick Insect

Hector the Robot Mimics a Giant Stick Insect

Reuters - Innovations Video Online (Jan. 26, 2015) A robot based on a stick insect can navigate difficult terrain autonomously and adapt to its surroundings. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Scientists Model Flying, Walking Drone After Vampire Bats

Scientists Model Flying, Walking Drone After Vampire Bats

Buzz60 (Jan. 26, 2015) Swiss scientists build a new drone that can both fly and walk, modeling it after the movements of common vampire bats. Jen Markham (@jenmarkham) has the story. Video provided by Buzz60
Powered by NewsLook.com
Obama's Wildlife Plan Renews Alaska Drilling Debate

Obama's Wildlife Plan Renews Alaska Drilling Debate

Newsy (Jan. 26, 2015) President Obama&apos;s proposal aims to protect more land in the Arctic National Wildlife Refuge, but so far, all that&apos;s materialized is a war of words. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins