Featured Research

from universities, journals, and other organizations

Chemotherapy Might Help Cancer Vaccines Work

Date:
May 18, 2008
Source:
Duke University Medical Center
Summary:
Chemotherapy given in conjunction with cancer vaccines may boost the immune system's response, potentially improving the effectiveness of this promising type of cancer therapy.

Chemotherapy given in conjunction with cancer vaccines may boost the immune system's response, potentially improving the effectiveness of this promising type of cancer therapy, according to a study by researchers in the Duke Comprehensive Cancer Center.

"Chemotherapy first knocks out T regulatory cells that suppress immune function and we speculated that this might have a complementary effect when used in conjunction with vaccines, which work by boosting immune function," said Timothy Clay, Ph.D., a researcher at Duke and a lead investigator on this study. "We tested this theory both pre-clinically and in patients who were part of a vaccine trial at Duke for gastrointestinal cancers, and found that our hypothesis seemed to be true."

Researchers used a drug called denileukin diftitox (ONTAK) for this study; the drug is routinely used to treat a type of lymphoma and is known to deplete certain types of immune cells including the T regulatory cells that "put the brakes" on immune function. They speculated it might facilitate better immune responses to a cancer vaccine.

"In the lab work, we definitely saw a heightened immune response when we used the denileukin diftitox in conjunction with the vaccine. The vaccine we used targets a protein found in gastrointestinal tumors and works by boosting immune response to the cells carrying that protein," Clay said. "From there, we gave the drug to 15 patients in a phase I study using the vaccine."

The researchers found that when multiple doses of the denileukin diftitox were given, immune response to the vaccine was enhanced in these patients.

"This is encouraging. The next step will be to develop better drugs that support vaccines by enhancing the immune response they depend on to work," Clay said. "It's a concept that can be applied to any type of solid tumor, which has huge implications for cancer research."

Vaccines are being used in clinical trials across the country to treat many malignancies, including lung cancer, brain tumors and colorectal cancer.

The researchers will present their findings at the annual American Society of Clinical Oncology meeting in Chicago, on May 31. The study was funded by the National Cancer Institute.

Other researchers involved in this study include Amy Hobeika, Takuya Osada, Delila Serra, Donna Niedzwiecki, H. Kim Lyerly and Michael Morse.


Story Source:

The above story is based on materials provided by Duke University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Duke University Medical Center. "Chemotherapy Might Help Cancer Vaccines Work." ScienceDaily. ScienceDaily, 18 May 2008. <www.sciencedaily.com/releases/2008/05/080515215901.htm>.
Duke University Medical Center. (2008, May 18). Chemotherapy Might Help Cancer Vaccines Work. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2008/05/080515215901.htm
Duke University Medical Center. "Chemotherapy Might Help Cancer Vaccines Work." ScienceDaily. www.sciencedaily.com/releases/2008/05/080515215901.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins