Featured Research

from universities, journals, and other organizations

New Prognostic Markers For Gastric Cancer Patients

Date:
May 20, 2008
Source:
World Journal of Gastroenterology
Summary:
In a recent study to understand the coordinated regulation of cell-cell and cell-matrix interactions during malignant transformation, the researchers studied the coexpression of E-cadherin£¬syndecan-1 and integrin beta3 by immunohistochemical study in gastric carcinomas. The results from the study confirm the correlation between expressions of cell adhesion molecules (CAMs) and gastric cancer. They suggest the coexpression of these can be used to identify the prognosis of gastric carcinoma.

In a recent study to understand the coordinated regulation of cell-cell and cell-matrix interactions during malignant transformation, the researchers studied the coexpression of E-cadherin£¬syndecan-1 and integrin beta3 by immunohistochemical study in gastric carcinomas. The results from the study confirm the correlation between expressions of cell adhesion molecules (CAMs) and gastric cancer. They suggest the coexpression of these can be used to identify the prognosis of gastric carcinoma.

Related Articles


In standard clinical settings, DNA microarrays are currently unsuitable for routine use. Prognostic classification on formalin-fixed paraffin-embedded tissues is required. In this study, we looked for new molecular markers for identifying the prognosis of gastric cancer patients.

This study was performed by a team led by Professor Zhong-Sheng Zhao.

The team identified that syndecan-1, E-cadherin and integrins highly correlated with each other as intracellular adhesion molecular complexes. We suggest the results of co-examination of them can be important indexes for the prognosis of gastric carcinoma. In the view of the authors, to date no clear mechanism has been found to explain the interaction of the three molecules, and no clinical research has been done to verify the findings.

Traditional clinicopathologic factors and several interesting molecules, including cell cycle regulation factors such as p27 or cyclin E, cell adhesion molecules such as E-cadherin, angiogenic factors such as vascular endothelial growth factor and placenta growth factor, oncogenes such as c-erbB2 and c-myc, and tumor suppressor genes such as p53, have been reported to correlate to the prognosis of gastric cancer patients. Cell adhesion is one of important steps in the multi-step process of gastric cancer pathogenesis.

Further research should collect more samples and emphasize the importance of studying multiple genetic alterations in concert.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chu YQ, Ye ZY, Tao HQ, Wang YY, Zhao ZS. Relationship between cell adhesion molecules expression and the biological behavior of gastric carcinoma. World J Gastroenterol 2008; 14(13): 1990-1996 [link]

Cite This Page:

World Journal of Gastroenterology. "New Prognostic Markers For Gastric Cancer Patients." ScienceDaily. ScienceDaily, 20 May 2008. <www.sciencedaily.com/releases/2008/05/080520122738.htm>.
World Journal of Gastroenterology. (2008, May 20). New Prognostic Markers For Gastric Cancer Patients. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2008/05/080520122738.htm
World Journal of Gastroenterology. "New Prognostic Markers For Gastric Cancer Patients." ScienceDaily. www.sciencedaily.com/releases/2008/05/080520122738.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) — The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins