Featured Research

from universities, journals, and other organizations

The Protein Hip1r Soothes The Stomach

Date:
June 5, 2008
Source:
Journal of Clinical Investigation
Summary:
New data, generated in mice have defined a new role for the protein Hip1r in ensuring that cells in the lining of the stomach that are known as parietal cells function normally. One of the main functions of parietal cells is to secrete acid, which is stored inside special compartments in the cell known as vesicles, into the stomach to promote the digestion of food.

New data, generated in mice, by Linda Samuelson and colleagues, at the University of Michigan, Ann Arbor, have defined a new role for the protein Hip1r in ensuring that cells in the lining of the stomach that are known as parietal cells function normally.

Related Articles


One of the main functions of parietal cells is to secrete acid, which is stored inside special compartments in the cell known as vesicles, into the stomach to promote the digestion of food. As Hip1r was found to be required for parietal cells to transport their acid-containing vesicles to the surface where the acid is released, mice lacking Hip1r had less acid in their stomach.

In addition, the defect in acid-containing vesicle transport caused many of the parietal cells to die by a process known as apoptosis. These effects were associated with other changes in the lining of the stomach that resembled changes seen in the human stomach lining in the progression to stomach cancer.

The authors therefore conclude that Hip1r has an important role in maintaining normal stomach function.



Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice. Journal of Clinical Investigation, June 5, 2008

Cite This Page:

Journal of Clinical Investigation. "The Protein Hip1r Soothes The Stomach." ScienceDaily. ScienceDaily, 5 June 2008. <www.sciencedaily.com/releases/2008/06/080605181207.htm>.
Journal of Clinical Investigation. (2008, June 5). The Protein Hip1r Soothes The Stomach. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2008/06/080605181207.htm
Journal of Clinical Investigation. "The Protein Hip1r Soothes The Stomach." ScienceDaily. www.sciencedaily.com/releases/2008/06/080605181207.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins