Featured Research

from universities, journals, and other organizations

The Protein Hip1r Soothes The Stomach

Date:
June 5, 2008
Source:
Journal of Clinical Investigation
Summary:
New data, generated in mice have defined a new role for the protein Hip1r in ensuring that cells in the lining of the stomach that are known as parietal cells function normally. One of the main functions of parietal cells is to secrete acid, which is stored inside special compartments in the cell known as vesicles, into the stomach to promote the digestion of food.

New data, generated in mice, by Linda Samuelson and colleagues, at the University of Michigan, Ann Arbor, have defined a new role for the protein Hip1r in ensuring that cells in the lining of the stomach that are known as parietal cells function normally.

One of the main functions of parietal cells is to secrete acid, which is stored inside special compartments in the cell known as vesicles, into the stomach to promote the digestion of food. As Hip1r was found to be required for parietal cells to transport their acid-containing vesicles to the surface where the acid is released, mice lacking Hip1r had less acid in their stomach.

In addition, the defect in acid-containing vesicle transport caused many of the parietal cells to die by a process known as apoptosis. These effects were associated with other changes in the lining of the stomach that resembled changes seen in the human stomach lining in the progression to stomach cancer.

The authors therefore conclude that Hip1r has an important role in maintaining normal stomach function.



Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice. Journal of Clinical Investigation, June 5, 2008

Cite This Page:

Journal of Clinical Investigation. "The Protein Hip1r Soothes The Stomach." ScienceDaily. ScienceDaily, 5 June 2008. <www.sciencedaily.com/releases/2008/06/080605181207.htm>.
Journal of Clinical Investigation. (2008, June 5). The Protein Hip1r Soothes The Stomach. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2008/06/080605181207.htm
Journal of Clinical Investigation. "The Protein Hip1r Soothes The Stomach." ScienceDaily. www.sciencedaily.com/releases/2008/06/080605181207.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins