Featured Research

from universities, journals, and other organizations

Improving Brain Function In Rats Following A Stroke

Date:
June 8, 2008
Source:
Journal of Clinical Investigation
Summary:
Researchers have now shown that rats transplanted with cells isolated from human nasal polyps have improved brain function following a stroke compared with rats not transplanted with these cells.

A team of researchers from Academia Sinica, Taipei, Republic of China, and China Medical University Hospital, Taichung, Republic of China, have now shown that rats transplanted with cells isolated from human nasal polyps have improved brain function following a stroke compared with rats not transplanted with these cells.

The authors therefore suggest that isolating these cells from individuals who have had a stroke and transplanting them back into the brains of these individuals might provide clinical benefit.

In the study, cells known as olfactory ensheathing cells (OECs) and olfactory nerve fibroblasts (ONFs) were isolated from human nasal polyps and characterized in vitro. Rats implanted with human OECs and ONFs performed better in tasks measuring their brain function (e.g., tasks assessing their movement) following a stroke than did rats not transplanted with these cells.

Further work determined some of the mechanisms by which OECs and ONFs mediated their beneficial effects.

Specifically, OECs and ONFs induced nerve cell growth by a process that involved increased expression of the soluble factor SDF-1-alpha, the protein to which it binds, and cellular prion protein. In addition, when transplanted into mice, OECs and ONFs induced stem cells to home to the site of brain damage following a stroke.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Implantation of olfactory ensheathing cells promotes neuroplasticity in murine models of stroke. Journal of Clinical Investigation, June 5, 2008

Cite This Page:

Journal of Clinical Investigation. "Improving Brain Function In Rats Following A Stroke." ScienceDaily. ScienceDaily, 8 June 2008. <www.sciencedaily.com/releases/2008/06/080605203618.htm>.
Journal of Clinical Investigation. (2008, June 8). Improving Brain Function In Rats Following A Stroke. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2008/06/080605203618.htm
Journal of Clinical Investigation. "Improving Brain Function In Rats Following A Stroke." ScienceDaily. www.sciencedaily.com/releases/2008/06/080605203618.htm (accessed September 2, 2014).

Share This




More Mind & Brain News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com
Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins