Featured Research

from universities, journals, and other organizations

New Molecular Link Between Diabetes And Kidney Failure

Date:
June 9, 2008
Source:
Journal of Clinical Investigation
Summary:
Diabetes is an increasingly common cause of kidney failure in developed countries. It is thought that activation of a hormone system known as the renin-angiotensin system (RAS) early in the course of diabetes has an important role in the development of kidney disease.

Diabetes is an increasingly common cause of kidney failure in developed countries. It is thought that activation of a hormone system known as the renin-angiotensin system (RAS) early in the course of diabetes has an important role in the development of kidney disease.

Related Articles


New data, generated using mice, rats, and rabbits, by János Peti-Peterdi and colleagues, at the University of Southern California, Los Angeles, have provided new insight into the mechanisms by which the RAS might be activated in individuals with diabetes.

Individuals with diabetes have increased levels of glucose in their blood and other bodily fluids. In the study, in vitro exposure of rat, mouse, and rabbit kidney to high levels of glucose triggered cells in the kidney to release renin and this was associated with accumulation of a molecule known as succinate.

Consistent with this having a role in human diabetes, diabetic mice had higher levels of succinate in their kidney than did nondiabetic mice.

Furthermore, diabetic mice lacking the protein GPR91, which recognizes succinate, had less renin in their kidney that did diabetic mice expressing GPR91. The authors therefore suggest that GPR91 might be a new therapeutic target to prevent the kidney failure that can be a complication of diabetes.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney. Journal of Clinical Investigation, June 5, 2008

Cite This Page:

Journal of Clinical Investigation. "New Molecular Link Between Diabetes And Kidney Failure." ScienceDaily. ScienceDaily, 9 June 2008. <www.sciencedaily.com/releases/2008/06/080605203740.htm>.
Journal of Clinical Investigation. (2008, June 9). New Molecular Link Between Diabetes And Kidney Failure. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2008/06/080605203740.htm
Journal of Clinical Investigation. "New Molecular Link Between Diabetes And Kidney Failure." ScienceDaily. www.sciencedaily.com/releases/2008/06/080605203740.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins