Featured Research

from universities, journals, and other organizations

Breakthrough In Understanding Tumor Immune Therapy: Induction Of Tumor Dormancy Instead Of Killing

Date:
June 15, 2008
Source:
Tuebingen University
Summary:
Researchers have uncovered an entirely new understanding on how the immune system may control tumor development. Until now it is strongly believed that the immune system controls growth of tumors by killing tumor cells. The researchers now show that immune responses can prevent tumor growth without killing tumor cells.

Researchers from the Tubingen University, Department of Dermatology, uncovered an entirely new understanding on how the immune system may control tumor development. Until now it is strongly believed that the immune system controls growth of tumors by killing tumor cells.

The Tubingen researchers, members of the Comprehensive Cancer Center, now show that immune responses can prevent tumor growth without killing tumor cells.

They used a model of endogenously growing tumors that develop, like many human tumors, because of a defect in normal cell death. The researchers show that the immune system can prevent tumor growth without destroying tumor cells. They show that early treatment of developing tumors arrests tumor development at very early stages through a strictly cytokine mediated mechanism. One of the important players that prevents the outgrowth of malignant tumors is interferon.

The researchers show further a second important aspect: Immune responses can both - either induce tumor dormancy or, unexpectedly, tumor growth. In the absence of either interferon or tumor necrosis factor the immune response converts the from a protective into a tumor promoting immune response.

In conclusion, the paper (published in Cancer Cell, 10.6.2008) gives a great hope and new aspects for the development of new tumor vaccines. They show that tumor immune responses can induce tumor dormancy, which means that the immune response arrests tumors at early stages.

Yet, these immune responses have to occur early in tumor development and have to provide the correct pattern of cytokines. In the case of an inappropriate cyto-kine pattern, i.e. missing interferon or missing tumor necrosis factor, the same response may dramatically enhance tumor growth.


Story Source:

The above story is based on materials provided by Tuebingen University. Note: Materials may be edited for content and length.


Cite This Page:

Tuebingen University. "Breakthrough In Understanding Tumor Immune Therapy: Induction Of Tumor Dormancy Instead Of Killing." ScienceDaily. ScienceDaily, 15 June 2008. <www.sciencedaily.com/releases/2008/06/080611183015.htm>.
Tuebingen University. (2008, June 15). Breakthrough In Understanding Tumor Immune Therapy: Induction Of Tumor Dormancy Instead Of Killing. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/06/080611183015.htm
Tuebingen University. "Breakthrough In Understanding Tumor Immune Therapy: Induction Of Tumor Dormancy Instead Of Killing." ScienceDaily. www.sciencedaily.com/releases/2008/06/080611183015.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins