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Better Treatments For Malaria In Pregnancy Are Needed

Date:
June 16, 2008
Source:
Public Library of Science
Summary:
Malaria in pregnancy threatens the life of both mother and child, and yet there has been very little research on how best to treat it, say malaria experts. Researchers describe a dangerous "catch-22" situation that prevents the health community from knowing whether new drugs, including new malaria drugs, are effective and safe in pregnancy.

Malaria in pregnancy threatens the life of both mother and child, and yet there has been very little research on how best to treat it, say a team of malaria experts in PLoS Medicine.

Nicholas J. White (Mahidol--Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand) and colleagues describe a dangerous "catch-22" situation that prevents the health community from knowing whether new drugs, including new malaria drugs, are effective and safe in pregnancy.

"Since the disaster of thalidomide 50 years ago," they say, "the medical profession has been rightfully very cautious about giving newly developed drugs to pregnant women, for fear that they might damage the unborn baby." The result has been that new medicines often carry a prescribing caveat that they not be used in pregnancy. In fact, there may have been no worrying results from reproductive toxicology testing to warrant this caution--simply insufficient clinical information in pregnancy. Pregnant women with potentially fatal illnesses may thus be treated with inferior drugs to avoid a hypothetical risk to the unborn child, and the consequent liability.

This situation in turn leads to a "dangerous catch-22": new medicines that might be life-saving are not prescribed in pregnancy, and since they are not prescribed it is impossible to know whether they are effective and safe. Recognizing this catch-22, regulatory authorities in developed countries have begun to encourage pharmaceutical companies to gather information on the use of new drugs in pregnancy. But in the developing world, there are few or no studies in pregnancy on most drugs used for treating tropical infections such as malaria--and so there are often no recommendations for treating these infections based on good medical research.

Establishing the efficacy and safety of new malaria medicines in pregnancy should be an urgent priority, argue White and colleagues: "International agencies and funders need to provide adequate support for quality studies in pregnancy and, in an increasingly litigious climate, to underwrite the liabilities."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. White et al. New Medicines for Tropical Diseases in Pregnancy: Catch-22. PLoS Medicine, 2008; 5 (6): e133 DOI: 10.1371/journal.pmed.0050133

Cite This Page:

Public Library of Science. "Better Treatments For Malaria In Pregnancy Are Needed." ScienceDaily. ScienceDaily, 16 June 2008. <www.sciencedaily.com/releases/2008/06/080616223437.htm>.
Public Library of Science. (2008, June 16). Better Treatments For Malaria In Pregnancy Are Needed. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2008/06/080616223437.htm
Public Library of Science. "Better Treatments For Malaria In Pregnancy Are Needed." ScienceDaily. www.sciencedaily.com/releases/2008/06/080616223437.htm (accessed July 25, 2014).

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