Featured Research

from universities, journals, and other organizations

Effectiveness Of Contrast Agent Cytate In Detecting Prostate Cancer

Date:
June 26, 2008
Source:
City College of New York
Summary:
Researchers have conducted time-resolved fluorescence measurement and optical imaging studies that demonstrate the efficacy of Cytate as a fluorescence marker to detect prostate cancer. Cytate, a contrast agent that conjugates to receptors on prostate cancer cells, exhibited greater fluorescence when applied to cancerous prostate tissue as opposed to normal prostate tissue.

Researchers at the Institute for Ultrafast Spectroscopy and Lasers (IUSL) at The City College of New York (CCNY) have conducted time-resolved fluorescence measurement and optical imaging studies that demonstrate the efficacy of Cytate as a fluorescence marker to detect prostate cancer. Cytate, a contrast agent that conjugates to receptors on prostate cancer cells, exhibited greater fluorescence when applied to cancerous prostate tissue as opposed to normal prostate tissue.

Related Articles


Prostate cancer accounts for approximately 29 percent of cancer occurrences among men. According to “CA: A Cancer Journal for Clinicians,” in 2007 it was responsible for 27,000 deaths in the United States. Early detection is important to reducing the death count.

Current noninvasive detection methods, which include digital exams, blood tests and ultrasound, have limited accuracy. “There is a need to develop a noninvasive technique for early detection of prostate cancer with higher accuracy and resolution,” said Dr. Robert R. Alfano, Distinguished Professor of Science and Engineering and Director of IUSL.

Cytate is dye-peptide conjugate consisting of Indocyanine Green (ICG), an FDA-approved near-infrared dye, and a somatostatin receptor ligand. Somatostatin is a small cyclic neuropeptide that is believed to regulate the production of other hormones and perform an important role in the cancer development. Previous studies had shown that Cytate could target somatostatin receptor-rich pancreas tumors in animal model because of its high affinity for the receptors.

The researchers performed ultrafast time-resolved fluorescence polarization measurements on Cytate solution as well as on cancerous and normal prostate tissue sample that were stained with Cytate. In addition, they conducted fluorescence imaging of two small pieces of Cytate-stained normal and cancerous prostate tissue sandwiched between larger pieces of normal prostate tissue.

While the latter technique reveals which sections of tissue indicate presence of cancer, the former how the molecules of Cytate around the stained areas are behaving, explained Dr. Wubao Wang, a senior researcher at project leader at IUSL.

The time-resolved fluorescence polarization study found the ratio for peak fluorescence intensity between the cancerous and normal tissue was around 3.57.

“Somatostatin receptors are over-expressed on cancererous cells relative to normal cells, so they adsorb more of the Cytate,” Professor Alfano added. “Cytate essentially is a smart reagent that attaches to cancerous cells. It is an excellent contrast agent because its absorption and fluorescence spectra line in the near-infrared ‘tissue optical window (800 nanometers – 1 micron).’”

The next step in the investigation is development of an optical probe called the “photonic finger” that can perform imaging of the prostate from inside the body, he said. The project’s ultimate goal is to develop reliable cancer detection techniques based on imaging as an alternative to biopsies.

The yet-to-be-developed probe unit was inspired by Dr. G. Nagamasu, a deceased urologist who was a personal friend of Professor Alfano. However, Professor Alfano added that before this can happen, a proven method needs to be developed for injecting Cytate into the patient.

The research was reported in “Applied Optics,” a journal published by the Optical Society of America, and wasselected for publication in the most recent issue of the "Virtual Journal for Biomedical Optics (VJBO)" by the editor-in-chief, Gregory Faris.

It wassupported by a grant from the U.S. Army Medical Research and Material Command. A new grant awarded to Dr. Wang is supporting development of the “photonic finger” near-infrared scanning polarization imaging unit. IUSL is seeking additional grants in biomedical optics to develop the compact unit and photonic explorers.

The research team: included Yang Pu, a Ph.D. candidate in electrical engineering; Dr. Wang; Dr. Bidyut Das, a scientist at IUSL; Dr. Samuel Achilefu, a researcher in the radiology department at Washington University School of Medicine, and Professor Alfano.


Story Source:

The above story is based on materials provided by City College of New York. Note: Materials may be edited for content and length.


Cite This Page:

City College of New York. "Effectiveness Of Contrast Agent Cytate In Detecting Prostate Cancer." ScienceDaily. ScienceDaily, 26 June 2008. <www.sciencedaily.com/releases/2008/06/080626102341.htm>.
City College of New York. (2008, June 26). Effectiveness Of Contrast Agent Cytate In Detecting Prostate Cancer. ScienceDaily. Retrieved November 21, 2014 from www.sciencedaily.com/releases/2008/06/080626102341.htm
City College of New York. "Effectiveness Of Contrast Agent Cytate In Detecting Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/06/080626102341.htm (accessed November 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins