Featured Research

from universities, journals, and other organizations

First Patients Implanted In Study Evaluating Deep Brain Stimulation For Depression

Date:
June 29, 2008
Source:
St. Jude Medical
Summary:
St. Jude Medical, Inc. has announced the first patient implants in a clinical study that is investigating whether deep brain stimulation (DBS) therapy will help people who suffer from major depressive disorder, a severe form of depression. The patients, a 59-year-old woman and a 42-year-old man, were implanted with the St. Jude Medical Libra® Deep Brain Stimulation System, an investigational device.

Illustration of the Libra Deep Brain Stimulation System, an investigational device being tested in clinical research studies for major depressive disorder. The Libra system sends mild electrical pulses to a specific target in the brain from a device implanted in the chest. This device was developed by the St. Jude Medical ANS Division.
Credit: Image provided by St. Jude Medical

St. Jude Medical, Inc. has announced the first patient implants in a clinical study that is investigating whether deep brain stimulation (DBS) therapy will help people who suffer from major depressive disorder, a severe form of depression. The patients, a 59-year-old woman and a 42-year-old man, were implanted at Alexian Brothers Behavioral Health Hospital in Chicago, with the St. Jude Medical Libra® Deep Brain Stimulation System, an investigational device.

The study, called BROADEN™ (BROdmann Area 25 DEep brain Neuromodulation), is a controlled, multi-site, blinded study that is evaluating the safety and effectiveness of DBS in patients with depression for whom currently available treatments are not effective.

“We are excited to be part of the first double-blind study of Deep Brain Stimulation for depression and remain hopeful that this therapy may prove beneficial for this seriously ill patient population,” said Anthony D'Agostino, M.D., medical director of Alexian Brothers Behavioral Health Hospital and the principal investigator at the study site. “The study is an important contribution to the advancement of treatment options for severely depressed patients.”

This study is researching a specific area in the brain called Brodmann Area 25 that is thought to be involved in depression. The first research of DBS for depression was conducted in Toronto, Canada, by neurologist Helen S. Mayberg, M.D., and neurosurgeon Andres Lozano, M.D., in 2003. They published their findings in Neuron in March 2005, reporting that brain imaging studies indicate that Brodmann Area 25 appears to be overactive in profoundly sad and depressed people.

St. Jude Medical owns the intellectual property rights, and has various patents issued and pending, for the use of neurostimulation at Brodmann Area 25. The Libra Deep Brain Stimulation System provides mild pulses of current from a device implanted near the collarbone and connected to small electrical leads placed at specific targets in the brain.

“This depression study represents a continuation of our commitment to provide solutions for those who are suffering and in need of additional therapy options,” said Chris Chavez, president of the St. Jude Medical ANS Division. “The Brodmann Area 25 study is an important step in bringing physicians and their patients a neuromodulation therapy that, if successful, will treat this debilitating form of depression.”

The National Institute of Mental Health estimates that more than 21 million U.S. adults suffer from some kind of depressive disorder. Current therapies are effective for about 80 percent of this patient population according to the National Advisory Mental Health Council. That means approximately 4 million adult Americans live with depression that doesn’t respond to medications, psychotherapy or electroconvulsive therapy.

To be eligible for this study, participants must:

  • Currently be diagnosed with major depressive disorder
  • Be between 21 and 70 years old, with onset of first episode before age 45
  • Have tried at least four treatments in their current episode, such as different medications, various combinations of medications or electroconvulsive therapy
  • Have been depressed for at least one year

For more information about this study, call toll-free at 866-787-4332 or visit http://www.BROADENstudy.com.


Story Source:

The above story is based on materials provided by St. Jude Medical. Note: Materials may be edited for content and length.


Cite This Page:

St. Jude Medical. "First Patients Implanted In Study Evaluating Deep Brain Stimulation For Depression." ScienceDaily. ScienceDaily, 29 June 2008. <www.sciencedaily.com/releases/2008/06/080626144441.htm>.
St. Jude Medical. (2008, June 29). First Patients Implanted In Study Evaluating Deep Brain Stimulation For Depression. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2008/06/080626144441.htm
St. Jude Medical. "First Patients Implanted In Study Evaluating Deep Brain Stimulation For Depression." ScienceDaily. www.sciencedaily.com/releases/2008/06/080626144441.htm (accessed July 25, 2014).

Share This




More Mind & Brain News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) — A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) — China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com
Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) — An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins