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Calpain Inhibitors Never Forget: Improving Memory In Alzheimer's Disease Mice

Date:
July 6, 2008
Source:
Journal of Clinical Investigation
Summary:
Overactivation of proteins known as calpains, which are involved in memory formation, has been linked to Alzheimer disease. Researchers have now shown that two different drugs that inhibit calpains can improve memory in a mouse model of Alzheimer's disease, leading them to suggest drugs that target calpains might stop or slow down the memory loss that occurs as Alzheimer's disease progresses.

Overactivation of proteins known as calpains, which are involved in memory formation, has been linked to Alzheimer disease.

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Ottavio Arancio and colleagues, at Columbia University, New York, have now shown that two different drugs that inhibit calpains can improve memory in a mouse model of Alzheimer disease (APP/PS1 mice), leading them to suggest drugs that target calpains might stop or slow down the memory loss that occurs as Alzheimer disease progresses.

It is thought that dysfunctional signaling between nerve cells contributes to the impaired cognition experienced by individuals with Alzheimer disease.

In the study, analysis of cells and tissue slices from APP/PS1 mice, specifically cells from the part of the brain known as the hippocampus and hippocampal slices, indicated that exposure to calpain inhibitors restored signaling between nerve cells to normal.

The authors therefore suggest that calpain inhibitors improve memory in APP/PS1 mice because they reestablish normal signaling between nerve cells.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ottavio Arancio et al. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. Journal of Clinical Investigation, July 1, 2008

Cite This Page:

Journal of Clinical Investigation. "Calpain Inhibitors Never Forget: Improving Memory In Alzheimer's Disease Mice." ScienceDaily. ScienceDaily, 6 July 2008. <www.sciencedaily.com/releases/2008/07/080701185115.htm>.
Journal of Clinical Investigation. (2008, July 6). Calpain Inhibitors Never Forget: Improving Memory In Alzheimer's Disease Mice. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2008/07/080701185115.htm
Journal of Clinical Investigation. "Calpain Inhibitors Never Forget: Improving Memory In Alzheimer's Disease Mice." ScienceDaily. www.sciencedaily.com/releases/2008/07/080701185115.htm (accessed March 27, 2015).

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