Featured Research

from universities, journals, and other organizations

Tumor Suppressor That Manages Cellular Cleaning And Recycling Proceses Identified

Date:
July 7, 2008
Source:
University of Southern California
Summary:
Researchers have identified a specific tumor suppressor that manages membrane traffic routes for cellular cleaning and recycling.

Researchers at the University of Southern California (USC) have identified a specific tumor suppressor that manages membrane traffic routes for cellular cleaning and recycling.

Related Articles


"Our studies indicate that UVRAG tumor suppressor functionally connects and manages two distinct but converged membrane traffic routes for garbage cleaning and cargo recycling," says Chengyu Liang, M.D., Ph.D., assistant professor of research in the Department of Molecular Microbiology and Immunology at the Keck School of Medicine of USC.

The study identified a novel mechanism of the UVRAG tumor suppressor in regulation of autophagy, a mechanism that enables cells to digest or turn over their own contents for maintaining homeostasis (a balanced, stable condition) and responding to various stresses.

Autophagy is marked by the assembly of specialized vesicles called autophagosomes (the cellular equivalent of garbage bags) that engulf damaged proteins, organelles and invading microbes. The "bagged garbage" is then delivered to lysosomes (the cell's garbage disposal system) through autophagic trafficking that involves autophagosome-lysosome fusion. This fusion disposes of waste with the help of lysosomal enzymes for recycling.

The findings of the study indicate that the tumor suppressor UVRAG not only facilities autophagosome formation, but also facilitates autophagosome maturation by association with the C Vps complex, a cellular machinery that facilitates membrane fusion.

In addition to identifying a novel mechanism of the UVRAG tumor suppressor in autophagy regulation, the study also identified UVRAG as an important effector protein in membrane trafficking and demonstrated the connection between endocytic and autophagic trafficking. The research conducted by Liang and colleagues with Jae U. Jung, Ph.D., professor and chair of the Department of Molecular Microbiology and Immunology at the Keck School of Medicine, suggests a functional connection and coordinated regulation of two distinct but converged membrane trafficking pathways.

"The report provides new insights into understanding some human diseases with compromised autophagic and endosomal trafficking, including cardiomyopathy (a disease of the heart muscle), myopathy (a neuromuscular disease), neuronal ceroid lipofuscinosis (genetic disorders of nerve cells) and Danon Disease )a genetic disorder characterized by heart problems)," Liang says.

The findings warrant further study into whether the UVRAG-mediated trafficking activity contributes to its tumor suppression function, she says.

The study was supported by grants from the U.S. Public Health Service and the Leukemia & Lymphoma Society.


Story Source:

The above story is based on materials provided by University of Southern California. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chengyu Liang, Jong-soo Lee, Kyung-Soo Inn, Michaela U. Gack, Qinglin Li, Esteban A. Roberts, Isabelle Vergne, Vojo Deretic, Pinghui Feng, Chihiro Akazawa and Jae U. Jung. Beclin 1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nature Cell Biology, July 2008 DOI: 10.1038/ncb1740

Cite This Page:

University of Southern California. "Tumor Suppressor That Manages Cellular Cleaning And Recycling Proceses Identified." ScienceDaily. ScienceDaily, 7 July 2008. <www.sciencedaily.com/releases/2008/07/080703113638.htm>.
University of Southern California. (2008, July 7). Tumor Suppressor That Manages Cellular Cleaning And Recycling Proceses Identified. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2008/07/080703113638.htm
University of Southern California. "Tumor Suppressor That Manages Cellular Cleaning And Recycling Proceses Identified." ScienceDaily. www.sciencedaily.com/releases/2008/07/080703113638.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins