Featured Research

from universities, journals, and other organizations

Aggressive Non-Hodgkin's Lymphoma (Mantle Cell Lymphoma) On The Rise

Date:
July 9, 2008
Source:
American Cancer Society
Summary:
A new study indicates that the incidence of mantle cell lymphoma, an aggressive type of non-Hodgkin's lymphoma, is on the rise, most frequently striking men, Caucasians and older individuals.

A new study indicates that the incidence of mantle cell lymphoma, an aggressive type of non-Hodgkin's lymphoma, is on the rise, most frequently striking men, Caucasians and older individuals. The study also reveals that most patients are diagnosed with advanced stages of the disease.

Related Articles


While research has documented a steady increase in non-Hodgkin's lymphoma over the past several decades, the prevalence of mantle cell lymphoma, an uncommon yet distinct subtype of this cancer, remains unknown.

Mantle cell lymphoma was first established as a type of lymphoma in 1992. It is a fast-growing cancer of the immune system that is characterized by small- to medium-size cancer cells that may be in the lymph nodes, spleen, bone marrow, blood or gastrointestinal system. Despite the availability of many different types of therapies, the cancer remains incurable.

To determine how many people have been diagnosed with mantle cell lymphoma since it was first recognized, Dr. Michael Wang of the University of Texas M.D. Anderson Cancer Center and colleagues examined cancer registry data from 1992 to 2004, the most recent year for which complete data are available.

The researchers analyzed the records of 2,459 patients (2.8 percent of all patients with non-Hodgkin's lymphoma) diagnosed with mantle cell lymphoma during the time period. They found men were more than twice as likely to be diagnosed with the disease as women, and Caucasians had the highest risk of all ethnic groups. Age was a significant risk factor, with people between the ages of 70 to 79 more likely to be diagnosed with mantle cell lymphoma than all other age groups. The data also revealed that almost three-quarters of all mantle cell patients were diagnosed with advanced disease (stage III and IV).

When looking at trends during the study period, Drs. Wang and Du and their team found that the incidence rates increased progressively over time. In 1992, only 2.7 people per 1,000,000 were diagnosed, compared with 6.9 people per 1,000,000 in 2004. The investigators noted that the cause of this remarkable increase in the incidence rate of the disease over the past 13 years is unknown.

Because mantle cell lymphoma often goes undetected until later stages, it has the poorest prognosis of all lymphomas. Despite the recent discovery of new anti-cancer therapies that have improved the survival rates of patients with various types of non-Hodgkin's lymphoma, there is no clear standard approach for treating mantle cell lymphoma.

"A better understanding of the epidemiology of mantle cell lymphoma, the development of novel agents, more research funding and increased public awareness are all needed," the authors write.


Story Source:

The above story is based on materials provided by American Cancer Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yuhong Zhou, Haijun Wang, Wenjing Fang, Jorge E. Romaguer, Yanxia Zhang, Kay B. Delasalle, Larry Kwak, Qing Yi, Xianglin L. Du, and Michael Wang. Incidence trends of mantle cell lymphoma in the United States between 1992 and 2004. Cancer, Print Date: August 15, 2008 (Online: July 07, 2008) DOI: 10.1002/cncr.23608

Cite This Page:

American Cancer Society. "Aggressive Non-Hodgkin's Lymphoma (Mantle Cell Lymphoma) On The Rise." ScienceDaily. ScienceDaily, 9 July 2008. <www.sciencedaily.com/releases/2008/07/080707081821.htm>.
American Cancer Society. (2008, July 9). Aggressive Non-Hodgkin's Lymphoma (Mantle Cell Lymphoma) On The Rise. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2008/07/080707081821.htm
American Cancer Society. "Aggressive Non-Hodgkin's Lymphoma (Mantle Cell Lymphoma) On The Rise." ScienceDaily. www.sciencedaily.com/releases/2008/07/080707081821.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins