Featured Research

from universities, journals, and other organizations

Disruption Of Blood Sugar Levels After Heart Surgery Is Common

Date:
July 9, 2008
Source:
University of Bristol
Summary:
Inadequate blood sugar control in patients having heart surgery is associated with a four fold increase in post-surgery death and major complications -- and the blood sugar disturbances occur in patients with and without diabetes.

A study reveals that inadequate blood sugar control in patients having heart surgery is associated with a four fold increase in post-surgery death and major complications - and that the blood sugar disturbances occur in patients with and without diabetes.

The research from the University of Bristol was funded by the British Heart Foundation (BHF) and Garfield Weston Trust and is published today in Circulation. The study involved nearly 9,000 patients and showed that disturbed blood sugar control occurred not only in known diabetics, but that more than half of heart patients who developed moderate to poor blood sugar control post-surgery were not thought to be diabetic.

Diabetes has long been associated with a poor clinical outcome following heart surgery and there have been a number of advances in operative and intensive care techniques for diabetic heart patients. These findings have new and major implications for the treatment of heart patients as they suggest that inadequate control of blood sugar irrespective of diabetes mellitus is associated with four-fold increase of in-hospital mortality and major complications including heart attack (2.7 fold increase), neurological, kidney, lung and gastrointestinal injury.

The study, led by Dr Raimondo Ascione, Reader and Consultant in Cardiac Surgery at the Bristol Heart Institute, urges surgeons and intensive care specialists to use strict protocols of active blood sugar control in all patients admitted for major surgery. The effectiveness of these protocols and the biological mechanisms that lead to this problem also need to be investigated with rigorous research.

Dr Ascione said: "Currently, the absence of recognised guidelines is creating confusion on how to face the challenge of clinical conditions other than diabetes leading to derangement of glucose metabolism. The lack of rigorous research in this field does not help.

"Important clinical decisions are often left to the individual clinician. These include: which screening tests, if any, to use on admission; whether or not to use a blood glucose control strategy during hospital stay, which level of blood glucose to target, and whether this targeting has to be strict or lenient."

This confusion has resulted in:

  • a lack of consistency worldwide in defining glucose metabolism-related conditions other than diabetes such as undiagnosed diabetes, stress hyperglycaemia, and inadequate blood glucose control;
  • a marked difference in assessing the extent of the problem (for example, in the United States, the prevalence of diabetes in patients undergoing coronary artery bypass graft is 35 to 40 per cent but in the UK it is only 18 to 20 per cent - almost certainly an underestimate because many diabetics are undiagnosed; nevertheless, in both countries these numbers do not take into account the condition of inadequate BGC irrespective of diabetes);
  • significant discrepancy in the treatment of patients, often even within the same unit, the impact of which remains uncertain.

Dr Ascione continued: "We believe that the findings of our study might apply also to all those non-cardiac surgery patients admitted for any other major surgical procedure worldwide. This might have serious implications for patients life expectancy and place an enormous burden on hospital resources."

Professor Peter Weissberg, Medical Director of the BHF, who co-funded the study, said: "While previous research has shown blood sugar levels have an important impact on the outcome of patients suffering a heart attack, this study shows for the first time the same may also be true for patients undergoing heart surgery.

"This research provides the basis for further, in depth studies to try to understand how better sugar control can help save more lives during and after heart surgery."


Story Source:

The above story is based on materials provided by University of Bristol. Note: Materials may be edited for content and length.


Cite This Page:

University of Bristol. "Disruption Of Blood Sugar Levels After Heart Surgery Is Common." ScienceDaily. ScienceDaily, 9 July 2008. <www.sciencedaily.com/releases/2008/07/080707161414.htm>.
University of Bristol. (2008, July 9). Disruption Of Blood Sugar Levels After Heart Surgery Is Common. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2008/07/080707161414.htm
University of Bristol. "Disruption Of Blood Sugar Levels After Heart Surgery Is Common." ScienceDaily. www.sciencedaily.com/releases/2008/07/080707161414.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins