Featured Research

from universities, journals, and other organizations

Combating Urinary Schistosomiasis: Both Metrifonate And Praziquantel Can Be Used

Date:
July 15, 2008
Source:
Wiley-Blackwell
Summary:
In 2000 the World Health Organization stopped recommending metrifonate for treating urinary schistosomiasis because the drug did not appear to be as effective as the treatment of choice, praziquantel. Now a systematic review published in the latest edition of The Cochrane Library indicates that both metrifonate and praziquantel are effective at treating the infection.

In 2000 the World Health Organization (WHO) stopped recommending metrifonate for treating urinary schistosomiasis because the drug did not appear to be as effective as the treatment of choice, praziquantel. Now a systematic review published in the latest edition of The Cochrane Library indicates that both metrifonate and praziquantel are effective at treating the infection.

The team of researchers who carried out this study suggest that metrifonate may be a valid addition to the current one-drug strategy against urinary schistosomiasis.

These findings were reached after considering the data in 24 trials that together involved 6,315 participants.

Urinary schistosomiasis occurs when a tiny worm, a blood fluke (Schistosoma haematobium), penetrates a person's skin while walking or bathing in fresh water contaminated with snails that contain the worm. The fluke lays eggs in the body, and these eggs cause tissue damage that leads to blood in urine and pain on passing urine. If left untreated they can cause serious disease including kidney failure. Estimates indicate that more than 100 million people in African and Eastern Mediterranean regions are infected by the flukes, resulting in considerable social and economic hardships.

Praziquantel requires only one dose and is operationally more convenient, while metrifonate requires three at 14-day intervals. This could be a strong reason for stopping metrifonate use, especially in rural community-based treatment programmes, where it is difficult to give multiple doses. However, the researchers believe that it would be prudent to have more than one drug in use in order to minimise the chance of the organism developing resistance against the only drug, praziquantel.

"Relying only on praziquantel for treating schistosomiasis is a risky strategy as it could encourage the development of drug resistance," says lead researcher Anthony Danso-Appiah, who works at the Liverpool School of Tropical Medicine, Liverpool, UK.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "Combating Urinary Schistosomiasis: Both Metrifonate And Praziquantel Can Be Used." ScienceDaily. ScienceDaily, 15 July 2008. <www.sciencedaily.com/releases/2008/07/080715204826.htm>.
Wiley-Blackwell. (2008, July 15). Combating Urinary Schistosomiasis: Both Metrifonate And Praziquantel Can Be Used. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2008/07/080715204826.htm
Wiley-Blackwell. "Combating Urinary Schistosomiasis: Both Metrifonate And Praziquantel Can Be Used." ScienceDaily. www.sciencedaily.com/releases/2008/07/080715204826.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins