Featured Research

from universities, journals, and other organizations

Gene That Regulates And Blocks Ovulation Discovered

Date:
July 17, 2008
Source:
University of Montreal
Summary:
Researchers have unlocked the mystery of a gene with the potential to both regulate and block ovulation. The findings could lead to the development of pharmaceuticals that activate the Lrh1 gene, which may prove critical in giving infertile couples hope in producing children.

A group of Canadian and European researchers have unlocked the mystery of a gene with the potential to both regulate and block ovulation. The new study is a collaboration between the Université de Montréal in Canada and the Institut de génetique et biologie moléculaire et cellulaire of the Université de Louis Pasteur, Strasbourg, France.

Related Articles


"Our findings demonstrate that the Lrh1 gene is essential in regulating ovulation," said Bruce D. Murphy, director the Animal Research Centre at the Faculty of Veterinary Medicine and an adjunct professor of and obstetrics and gynaecology at the Faculty of Medicine of the Université de Montréal. "Until this point, the role of Lrh1 in female fertility was unclear, but we have found the gene regulates multiple mechanisms of ovulation and may affect fertilization."

To reach their conclusions, the research team developed a new type of genetically modified mouse whose Lrh1 gene was selectively blocked in the ovary. They found that deletion of the Lrh1 gene effectively stopped ovulation. "This discovery means we can envision new contraceptives that selectively stop ovulation," said Dr. Murphy. "If created, these new contraceptives would be more effective and produce less side-effects than current steroid-based forms of birth control."

What's more, the findings could lead to the development of pharmaceuticals that activate the Lrh1 gene, which may prove critical in giving infertile couples hope in producing children. "This is an important development, since 15 percent of couples are infertile," said Dr. Murphy. "The widespread role of this gene in the ovary indicates that it may be targeted to stimulate ovulation and, eventually, conception."

The research was supported by the CIHR in Canada; CNRS, INSERM and the Serono Foundation in Europe.


Story Source:

The above story is based on materials provided by University of Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rajesha Duggavathi, Bruce D. Murphy, , David H. Volle, Chikage Mataki, Maria C. Antal, Nadia Messaddeq, Johan Auwerx and Kristina Schoonjans. Lrh1 regulates ovulation and fertility. Genes & Development, (in press)

Cite This Page:

University of Montreal. "Gene That Regulates And Blocks Ovulation Discovered." ScienceDaily. ScienceDaily, 17 July 2008. <www.sciencedaily.com/releases/2008/07/080717111937.htm>.
University of Montreal. (2008, July 17). Gene That Regulates And Blocks Ovulation Discovered. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2008/07/080717111937.htm
University of Montreal. "Gene That Regulates And Blocks Ovulation Discovered." ScienceDaily. www.sciencedaily.com/releases/2008/07/080717111937.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins