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Loss Of Stability Of The AHI1-HAP1 Complex An Issue In Joubert Syndrome

Date:
July 17, 2008
Source:
Journal of Clinical Investigation
Summary:
Joubert syndrome is an inherited brain disorder characterized by loss of muscle tone, developmental delay, and mental retardation. New research has provided insight into how mutations in one of the many genes linked to Joubert syndrome, AHI1, might cause disease. It is hoped that this might provide new targets for the development of novel therapeutic approaches.

Joubert syndrome is an inherited disorder that affects the area of the brain that controls balance and coordination; it is characterized by symptoms such as loss of muscle tone, developmental delay, and mental retardation. Mutations in several genes have been associated with Joubert syndrome.

The mutations in one of these, AHI1, are known to generate truncated forms of the AHI1 protein but how this contributes to the development of disease has not been determined. However, Xiao-Jiang Li and colleagues have now provided insight into this issue by showing that mouse Ahi1 interacts with the protein Hap1, which is critical for neonatal development.

In the study, it was found that Ahi1 binds tightly to Hap1 and that they form a stable complex in the mouse brain. Further analysis indicated that the two proteins stabilize each other and that truncated mouse Ahi1 that resembled the truncated AHI1 protein observed in individuals with Joubert syndrome was unable to stabilize mouse Hap1.

The ability of Hap1 and Ahi1 to stabilize each other was important for maintaining levels of the protein TrkB, which is critical for the generation of nerves and brain development. These data have provided insight into the mechanisms underlying disease in individuals with Joubert syndrome associated with AHI1 mutations and might provide new targets for the development of novel therapeutic approaches.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. Journal of Clinical Investigation, July 18, 2008

Cite This Page:

Journal of Clinical Investigation. "Loss Of Stability Of The AHI1-HAP1 Complex An Issue In Joubert Syndrome." ScienceDaily. ScienceDaily, 17 July 2008. <www.sciencedaily.com/releases/2008/07/080717180104.htm>.
Journal of Clinical Investigation. (2008, July 17). Loss Of Stability Of The AHI1-HAP1 Complex An Issue In Joubert Syndrome. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2008/07/080717180104.htm
Journal of Clinical Investigation. "Loss Of Stability Of The AHI1-HAP1 Complex An Issue In Joubert Syndrome." ScienceDaily. www.sciencedaily.com/releases/2008/07/080717180104.htm (accessed April 19, 2014).

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