Featured Research

from universities, journals, and other organizations

Testosterone Predominance Increases Prevalence Of Metabolic Syndrome During Menopause

Date:
July 30, 2008
Source:
Rush University Medical Center
Summary:
As testosterone progressively dominates the hormonal milieu during the menopausal transition, the prevalence of metabolic syndrome increases according to a new study by researchers at Rush University Medical Center. The study suggests this may be a pathway by which cardiovascular disease increases during menopause.

As testosterone progressively dominates the hormonal milieu during the menopausal transition, the prevalence of metabolic syndrome increases according to a new study by researchers at Rush University Medical Center. The study suggests this may be a pathway by which cardiovascular disease increases during menopause. The study is published in the July 28 issue of the Archives of Internal Medicine, one of the JAMA/Archives journals.

Related Articles


Cardiovascular disease is the primary cause of death in women in Western countries. Women tend to develop the disease about 10 years later than men with a marked increase through the menopausal years. Cardiovascular disease is rare among women younger than 45 years, but women older than 55 years are more likely than men to have cardiovascular disease.

Metabolic syndrome is a summary measure of important cardiovascular disease risk factors that frequently coexist. The syndrome is evident in 20% to 30% of middle-aged women and has been linked to the development of cardiovascular disease and diabetes.

The longitudinal, 9-year-study of 949 participants in the Study of Women’s Health Across the Nation (SWAN) shows that the incidence of metabolic syndrome increased progressively from six years before to six years after the final menstrual period, independent of aging and other known cardiovascular disease risk factors. The increase is steeper during the menopausal transition compared to the post menopausal years.

“Menopause-related testosterone predominance appears to be implicated as a key hormonal change that is associated with the incidence of metabolic syndrome,” said lead investigator Imke Janssen, PhD, assistant professor, Department of Preventive Medicine at Rush University Medical Center.

It was previously thought that estrogen exerted a direct positive effect on cardiovascular disease risk in women, a benefit that was lost as women transitioned from a premenopausal to a postmenopausal state and experienced a loss of estrogen.

“Our study data shows that the change in estrogen level is, at best, a weak and nonsignificant predictor of metabolic syndrome risk,” said Janssen. “A more likely story is that the progressive testosterone predominance exerts a direct negative effect on cardiovascular risk.”

The SWAN study is a multiethnic, community –based, longitudinal cohort study of the natural history of the menopausal transition in over 3300 women enrolled in seven sites throughout the United States.


Story Source:

The above story is based on materials provided by Rush University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Rush University Medical Center. "Testosterone Predominance Increases Prevalence Of Metabolic Syndrome During Menopause." ScienceDaily. ScienceDaily, 30 July 2008. <www.sciencedaily.com/releases/2008/07/080729133609.htm>.
Rush University Medical Center. (2008, July 30). Testosterone Predominance Increases Prevalence Of Metabolic Syndrome During Menopause. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2008/07/080729133609.htm
Rush University Medical Center. "Testosterone Predominance Increases Prevalence Of Metabolic Syndrome During Menopause." ScienceDaily. www.sciencedaily.com/releases/2008/07/080729133609.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins