Featured Research

from universities, journals, and other organizations

Better Bandage: Microscopic Scaffolding Offers 'Simple' Solution To Treating Skin Injuries

Date:
August 11, 2008
Source:
Engineering and Physical Sciences Research Council (EPSRC)
Summary:
A revolutionary dissolvable scaffold for growing new areas of skin could provide a safer, more effective way of treating burns, diabetic ulcers and similar injuries. This ultra-fine, 3-dimensional scaffold, which is made from specially developed polymers, looks similar to tissue paper but has fibres 100 times finer. Before it is placed over a wound, the patient's skin cells (obtained via a biopsy) are introduced and attach themselves to the scaffold, multiplying until they eventually grow over it.

A revolutionary dissolvable scaffold for growing new areas of skin could provide a safer, more effective way of treating burns, diabetic ulcers and similar injuries.

This ultra-fine, 3-dimensional scaffold, which is made from specially developed polymers, looks similar to tissue paper but has fibres 100 times finer. Before it is placed over a wound, the patient’s skin cells (obtained via a biopsy) are introduced and attach themselves to the scaffold, multiplying until they eventually grow over it. When placed over the wound, the scaffold dissolves harmlessly over 6 to 8 weeks, leaving the patient’s skin cells behind.

This new approach to skin reconstruction has been developed by a team of chemists, materials scientists and tissue engineers at the University of Sheffield, with funding from the Engineering and Physical Sciences Research Council. It is designed primarily for cases involving extensive burns where surgeons are unable to take enough skin grafts from elsewhere on the body to cover the damaged areas. Currently, bovine collagen or skin from human donors is used in these cases, but these approaches have potential health and rejection risks.

“Simplicity is the key,” says Professor Tony Ryan, who is leading the team. “Previous attempts to find better ways of encouraging skin cell growth have used chemical additives and other elaborate techniques to produce scaffolds, but their success has been limited. We’ve found that skin cells are actually very ‘smart’ – it’s in their DNA to sort themselves into the right arrangement. They just need a comparatively uncomplicated scaffold (and each other) to help them grow in a safe, natural way.”

The polymers used in the scaffold are biodegradable materials already approved for medical applications. Because the team has recognised that skin cells are ‘smart’ and the scaffold can therefore be ‘dumb’ (i.e. not overly sophisticated), simple polymers can be used.

The process for making the scaffolds is based on the well-known technique of electrospinning. However, the team has made a key advance by developing a new method of making, from the same biodegradable polymers, aligned-fibre ‘mats’ of potential use in promoting nerve or tendon growth. This method is currently being patented.

The next step in the research is to develop the skin reconstruction technology for clinical use, hopefully in the next few years. The technology also offers possibilities for testing the toxicity of cosmetic and similar products, using materials grown in the laboratory that closely resemble natural skin.

“Ultimately, we can envisage treatment of burns victims and the undertaking of reconstructive surgery using the scaffold and the patient’s own skin to produce bespoke skin for that patient,” says Professor Ryan. “As an accident-prone mountain biker, I find that prospect very attractive!”


Story Source:

The above story is based on materials provided by Engineering and Physical Sciences Research Council (EPSRC). Note: Materials may be edited for content and length.


Cite This Page:

Engineering and Physical Sciences Research Council (EPSRC). "Better Bandage: Microscopic Scaffolding Offers 'Simple' Solution To Treating Skin Injuries." ScienceDaily. ScienceDaily, 11 August 2008. <www.sciencedaily.com/releases/2008/08/080801074738.htm>.
Engineering and Physical Sciences Research Council (EPSRC). (2008, August 11). Better Bandage: Microscopic Scaffolding Offers 'Simple' Solution To Treating Skin Injuries. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2008/08/080801074738.htm
Engineering and Physical Sciences Research Council (EPSRC). "Better Bandage: Microscopic Scaffolding Offers 'Simple' Solution To Treating Skin Injuries." ScienceDaily. www.sciencedaily.com/releases/2008/08/080801074738.htm (accessed August 2, 2014).

Share This




More Health & Medicine News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins