Featured Research

from universities, journals, and other organizations

Sensitivity To Antidepressants Linked With TrkB-mediated Neural Proliferation

Date:
August 14, 2008
Source:
Cell Press
Summary:
Scientists have unveiled a functional link between production of new neurons and the effectiveness of antidepressants in an animal model. The study, published by Cell Press in the journal Neuron, provides exciting insight into a mechanism that might underlie a poor response to antidepressive medications for anxiety or depression.

Scientists have unveiled a functional link between production of new neurons and the effectiveness of antidepressants (ADs) in an animal model. The study, published by Cell Press in the August 14 issue of the journal Neuron, provides exciting insight into a mechanism that might underlie a poor response to antidepressive medications for anxiety or depression.

Related Articles


Depression is a significant public health problem due to both its high prevalence and its devastating impact on individuals and society," says senior author Dr. Luis F. Parada from the University of Texas Southwestern Medical Center. "Despite much excitement generated by recent advances in the knowledge of brain development and function, the mechanisms underlying the pathogenesis of depression, as well as its amelioration by AD treatment, remain poorly understood."

Animal studies have indicated that chronic treatment with ADs leads to production of new neurons in a part of the brain called the hippocampus. Exercise, such as running, which has a documented positive impact on mental health, also stimulates hippocampal neurogenesis. In both cases, new neurons arise from neural progenitor cells (NPCs) that seem to be required for the behavioral response to ADs.

Brain-derived neurotrophic factor (BDNF) is increased in the hippocampus after chronic AD treatment, has been linked with AD-like responses in several behavioral paradigms, and promotes proliferation of hippocampal NPCs. Interestingly, mutant mice with abnormal BDNF exhibit anxiety-like behaviors that are not normalized by AD treatment. Taken together, this research supports a role for BDNF in the response of the brain to chronic AD treatment.

To further investigate the relationship among BDNF, neurogenesis, and AD treatment, Dr. Parada and colleagues removed the gene for the BDNF receptor, TrkB, in a regional and cell type-specific manner. TrkB was expressed in hippocampal cells, including NPCs. Deletion of trkB in mouse embryos or adults resulted in impaired proliferation and neurogenesis in the hippocampus and prevented behavioral improvements induced by AD treatment or wheel running. Conversely, deletion of trkB from only mature neurons in the same brain regions did not impact the production of new neurons or behavioral responses to ADs.

The researchers went on to show that removal of TrkB from adult NPCs alone was sufficient to block sensitivity to chronic ADs. "Our data establish an essential cell-autonomous role for TrkB in regulating hippocampal neurogenesis and behavioral sensitivity to antidepressive treatments and support the notion that impairment of the neurogenic niche is an etiological factor for refractory responses to antidepressive regimen in mice," offers Dr. Parada.

The researchers include Yun Li, Bryan W. Luikart, Shari Birnbaum, Jian Chen, Chang-Hyuk Kwon, Steven G. Kernie, Rhonda Bassel-Duby, and Luis F. Parada, of the University of Texas Southwestern Medical Center, Dallas, TX.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Sensitivity To Antidepressants Linked With TrkB-mediated Neural Proliferation." ScienceDaily. ScienceDaily, 14 August 2008. <www.sciencedaily.com/releases/2008/08/080813120747.htm>.
Cell Press. (2008, August 14). Sensitivity To Antidepressants Linked With TrkB-mediated Neural Proliferation. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2008/08/080813120747.htm
Cell Press. "Sensitivity To Antidepressants Linked With TrkB-mediated Neural Proliferation." ScienceDaily. www.sciencedaily.com/releases/2008/08/080813120747.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins