Featured Research

from universities, journals, and other organizations

Sensitivity To Antidepressants Linked With TrkB-mediated Neural Proliferation

Date:
August 14, 2008
Source:
Cell Press
Summary:
Scientists have unveiled a functional link between production of new neurons and the effectiveness of antidepressants in an animal model. The study, published by Cell Press in the journal Neuron, provides exciting insight into a mechanism that might underlie a poor response to antidepressive medications for anxiety or depression.

Scientists have unveiled a functional link between production of new neurons and the effectiveness of antidepressants (ADs) in an animal model. The study, published by Cell Press in the August 14 issue of the journal Neuron, provides exciting insight into a mechanism that might underlie a poor response to antidepressive medications for anxiety or depression.

Related Articles


Depression is a significant public health problem due to both its high prevalence and its devastating impact on individuals and society," says senior author Dr. Luis F. Parada from the University of Texas Southwestern Medical Center. "Despite much excitement generated by recent advances in the knowledge of brain development and function, the mechanisms underlying the pathogenesis of depression, as well as its amelioration by AD treatment, remain poorly understood."

Animal studies have indicated that chronic treatment with ADs leads to production of new neurons in a part of the brain called the hippocampus. Exercise, such as running, which has a documented positive impact on mental health, also stimulates hippocampal neurogenesis. In both cases, new neurons arise from neural progenitor cells (NPCs) that seem to be required for the behavioral response to ADs.

Brain-derived neurotrophic factor (BDNF) is increased in the hippocampus after chronic AD treatment, has been linked with AD-like responses in several behavioral paradigms, and promotes proliferation of hippocampal NPCs. Interestingly, mutant mice with abnormal BDNF exhibit anxiety-like behaviors that are not normalized by AD treatment. Taken together, this research supports a role for BDNF in the response of the brain to chronic AD treatment.

To further investigate the relationship among BDNF, neurogenesis, and AD treatment, Dr. Parada and colleagues removed the gene for the BDNF receptor, TrkB, in a regional and cell type-specific manner. TrkB was expressed in hippocampal cells, including NPCs. Deletion of trkB in mouse embryos or adults resulted in impaired proliferation and neurogenesis in the hippocampus and prevented behavioral improvements induced by AD treatment or wheel running. Conversely, deletion of trkB from only mature neurons in the same brain regions did not impact the production of new neurons or behavioral responses to ADs.

The researchers went on to show that removal of TrkB from adult NPCs alone was sufficient to block sensitivity to chronic ADs. "Our data establish an essential cell-autonomous role for TrkB in regulating hippocampal neurogenesis and behavioral sensitivity to antidepressive treatments and support the notion that impairment of the neurogenic niche is an etiological factor for refractory responses to antidepressive regimen in mice," offers Dr. Parada.

The researchers include Yun Li, Bryan W. Luikart, Shari Birnbaum, Jian Chen, Chang-Hyuk Kwon, Steven G. Kernie, Rhonda Bassel-Duby, and Luis F. Parada, of the University of Texas Southwestern Medical Center, Dallas, TX.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Sensitivity To Antidepressants Linked With TrkB-mediated Neural Proliferation." ScienceDaily. ScienceDaily, 14 August 2008. <www.sciencedaily.com/releases/2008/08/080813120747.htm>.
Cell Press. (2008, August 14). Sensitivity To Antidepressants Linked With TrkB-mediated Neural Proliferation. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2008/08/080813120747.htm
Cell Press. "Sensitivity To Antidepressants Linked With TrkB-mediated Neural Proliferation." ScienceDaily. www.sciencedaily.com/releases/2008/08/080813120747.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins