Featured Research

from universities, journals, and other organizations

New Evidence On Addiction To Medicines: Diazepam Has Effect On Nerve Cells In The Brain Reward System

Date:
August 29, 2008
Source:
Academy of Finland
Summary:
Addictions to medicines and drugs are thought to develop over a relatively long period of time. The process involves both structural and functional changes in brain nerve cells that are still poorly understood. However, a single drug or alcohol dose is sufficient to generate an initial stage of addiction.

Addictions to medicines and drugs are thought to develop over a relatively long period of time. The process involves both structural and functional changes in brain nerve cells that are still poorly understood. However, a single drug or alcohol dose is sufficient to generate an initial stage of addiction.

Related Articles


Recent research conducted under the umbrella of the Academy of Finland Research Programme on Neuroscience (NEURO) has discovered the same phenomenon in the dosage of benzodiazepine diazepam.

Benzodiazepines are highly effective medicines that are widely used in the treatment of anxiety, insomnia, pains, panic attacks and other symptoms. However, over time patients may develop an increased tolerance towards these medicines and an unhealthy dependence.

"Previously, addiction to benzodiazepines has been explained by reference to negative rather than positive reinforcement. In other words, the thinking has been that the reason people continue to use the medicine is that it helps to alleviate their distressing withdrawal symptoms and general discomfort, rather than because it provides a sense of reward," says Professor Esa Korpi, who has been in charge of the research project at the University of Helsinki.

However, according to the latest research it seems that diazepam causes a similar change in the brain's reward-inducing dopamine cells as a dose of alcohol, morphine, amphetamine or cocaine. Furthermore, neural message transmission in the dopamine cells is reinforced for up to 72 hours after ingestion of diazepam. "Our studies have shown that diazepam also affects the dopamine system, which adds a new positive reinforcement mechanism of reward learning to the theory of benzodiazepine addiction," Korpi explains.


Story Source:

The above story is based on materials provided by Academy of Finland. Note: Materials may be edited for content and length.


Journal Reference:

  1. Heikkinen et al. Long-lasting Modulation of Glutamatergic Transmission in VTA Dopamine Neurons after a Single Dose of Benzodiazepine Agonists. Neuropsychopharmacology, 2008; DOI: 10.1038/npp.2008.89

Cite This Page:

Academy of Finland. "New Evidence On Addiction To Medicines: Diazepam Has Effect On Nerve Cells In The Brain Reward System." ScienceDaily. ScienceDaily, 29 August 2008. <www.sciencedaily.com/releases/2008/08/080827102742.htm>.
Academy of Finland. (2008, August 29). New Evidence On Addiction To Medicines: Diazepam Has Effect On Nerve Cells In The Brain Reward System. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2008/08/080827102742.htm
Academy of Finland. "New Evidence On Addiction To Medicines: Diazepam Has Effect On Nerve Cells In The Brain Reward System." ScienceDaily. www.sciencedaily.com/releases/2008/08/080827102742.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Tryptophan Isn't Making You Sleepy On Thanksgiving

Tryptophan Isn't Making You Sleepy On Thanksgiving

Newsy (Nov. 27, 2014) — Tryptophan, a chemical found naturally in turkey meat, gets blamed for sleepiness after Thanksgiving meals. But science points to other culprits. Video provided by Newsy
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins