Featured Research

from universities, journals, and other organizations

New Beta-blocker To Offer Hope To Heart And Lung Sufferers

Date:
August 28, 2008
Source:
University of Nottingham
Summary:
Researchers in the UK are developing new drug that could ease the suffering of hundreds of thousands of heart disease patients who are unable to take beta-blockers.

Researchers at The University of Nottingham have been awarded 2.8 million by the Wellcome Trust to develop a new drug that could ease the suffering of hundreds of thousands of heart disease patients who are unable to take beta-blockers.

Related Articles


In the UK, 2.6 million people suffer from heart disease and most are able to have their symptoms effectively managed with the prescription of beta-blocker drugs which stop adrenaline from making the heart work too hard.

However, a major side effect of beta-blockers is that they make the symptoms of asthma and other breathing problems worse, so that around 300,000 patients in the UK who also suffer from respiratory conditions are prevented from taking them.

Now, a team of scientists from the University’s Schools of Biomedical Sciences and Pharmacy will use the Wellcome Trust’s funding, made under the Seeding Drug Discovery initiative, to conduct a three-year study to develop a modified type of beta-blocker that will treat heart disease and angina without exacerbating any underlying respiratory problems..

If successful, the new drug could become the general medicine of choice for all heart patients because its targeted action will lead to a significant reduction in overall side effects.

Even the best currently available beta-blockers are poor at discriminating between the heart and lungs, causing the muscles in the lungs to tighten and making breathing more difficult in some patients who have a pre-existing lung complaint.

In patients suffering from asthma, in which environmental factors cause muscle contractions leading to a narrowing of the airway, taking these medicines can trigger an attack or, even if tolerated enough to be taken regularly, can stop other asthma drugs from working.

Doctors are also extremely wary in prescribing beta-blockers for patients suffering from heart disease and chronic obstructive pulmonary disease (COPD), a progressive condition which causes the destruction of lung tissue and increased mucus production, because any reduction in respiratory function that may be caused by the drugs could have a major impact on symptoms.

The Nottingham scientists have already developed a molecule that is much more effective at discriminating between the heart and lungs than current drugs. The funding will allow them to carry out further studies to improve the molecule to ensure that it is able to target the heart cells more effectively — therefore directing the therapeutic effect only to the heart and not the lungs. The aim is that the resulting drug will be long-lasting and could be taken orally.

Leading the research, Dr Jill Baker from the School of Biomedical Sciences said: “Once developed, this molecule will cause much less wheezing and shortness of breath and should be able to be given safely to the hundreds of thousands of patients with both heart and lung diseases. Furthermore, because it will have so few side effects, it has the potential to become the beta-blocker of choice for all heart patients.”

Dr Ted Bianco, Director of Technology Transfer at the Wellcome Trust, said: “We know that beta-blockers save lives in patients with heart disease, so making them safe for those unlucky enough to have a respiratory disorder as well is a clinical imperative. I applaud Jill Baker for questioning why beta-blockers should remain contraindicated for so many of her patients, and being stirred to correct this with an incisive programme of work. In the best traditions of medical research, this endeavour was born out of a problem encountered at the sharp end of clinical practice.”


Story Source:

The above story is based on materials provided by University of Nottingham. Note: Materials may be edited for content and length.


Cite This Page:

University of Nottingham. "New Beta-blocker To Offer Hope To Heart And Lung Sufferers." ScienceDaily. ScienceDaily, 28 August 2008. <www.sciencedaily.com/releases/2008/08/080828120322.htm>.
University of Nottingham. (2008, August 28). New Beta-blocker To Offer Hope To Heart And Lung Sufferers. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2008/08/080828120322.htm
University of Nottingham. "New Beta-blocker To Offer Hope To Heart And Lung Sufferers." ScienceDaily. www.sciencedaily.com/releases/2008/08/080828120322.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins