Featured Research

from universities, journals, and other organizations

Living Donor Liver Transplants May Drastically Decrease Mortality From Liver Failure

Date:
September 6, 2008
Source:
Wiley-Blackwell
Summary:
Patients with acute liver failure could be saved by a transplant from a living donor, according to a new study. The recent experience of US patients shows that recipient mortality rates and donor morbidity rates are acceptable.

Patients with acute liver failure (ALF) could be saved by a transplant from a living donor (LDLT), according to a new study. The recent experience of U.S. patients shows that recipient mortality rates and donor morbidity rates are acceptable.

Related Articles


Acute liver failure occurs more than 2,000 times per year in the United States and can quickly lead to coma and death. While spontaneous recovery can occur, for many patients the only effective therapy is liver transplantation. One-year survival for these transplant recipients is about 82 percent (just slightly less than for other indications) however, because of the shortage of donor livers, many patients with ALF die on the waiting list.

While other countries frequently use living donor liver transplantation for ALF patients, the treatment is rarely considered in the United States because of concerns about high post-operative mortality rates, risks to the donors, and whether donors can be appropriately evaluated during the rapid progression of ALF. The Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) provides a chance to study LDLT for ALF in the U.S. because it includes data from a large cohort of LDLT candidates at 9 U.S. transplant centers.

Researchers, led by James F. Trotter of the University of Colorado, report the outcomes of recipients with acute liver failure and their donors from the A2ALL study. It includes information from 1201 potential LDLT patients from January 1998 and April 2007. Just 14 (1 percent) of the patients had acute liver failure. Ten of these received LDLT, three received a liver from a deceased donor (DDLT), and 1 improved enough to be removed from the waiting list.

Survival rates were 70 percent after LDLT, compared to 67 percent of DDLT. Over a median of five years follow-up post-transplant, the nine surviving patients experienced 39 complications, a rate similar to other patients who'd undergone LDLT in the A2ALL study. Furthermore, the risks to the donors were acceptable—none died, while 50 percent experienced complications.

"This study demonstrates that LDLT may be performed safely in patients with ALF," the authors report. While the data was limited, and the patients may have been predicted to have more favorable outcomes than typical ALF patients, the findings are similar to the global experience with LDLT for ALF.

"In summary, these preliminary findings suggest that LDLT is a safe treatment option in selected patients with ALF," the authors conclude. "These results provide a rational basis for the continued, careful application of LDLT in patients with ALF."

An accompanying editorial by Chung Mau Lo of the University of Hong Kong, commends the authors for evaluating the role of LDLT for ALF in the United States. "The most striking finding was the rarity for patients with acute liver failure to be considered for LDLT in the United States," he writes.

"The concerns with the added donor risk and inferior recipient outcome which have led to the proscription of acute liver failure as an indication for LDLT in the New York Department of Health's guidelines were not borne out in the A2ALL study," Lo points out. Still, he suggests LDLT will continue to take a limited role in the United States, despite the potential for optimally timed liver transplant for patients with ALF.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Campsen et al. Outcomes of living donor liver transplantation for acute liver failure: The adult-to-adult living donor liver transplantation cohort study. Liver Transplantation, 2008; 14 (9): 1273 DOI: 10.1002/lt.21500

Cite This Page:

Wiley-Blackwell. "Living Donor Liver Transplants May Drastically Decrease Mortality From Liver Failure." ScienceDaily. ScienceDaily, 6 September 2008. <www.sciencedaily.com/releases/2008/09/080904215857.htm>.
Wiley-Blackwell. (2008, September 6). Living Donor Liver Transplants May Drastically Decrease Mortality From Liver Failure. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2008/09/080904215857.htm
Wiley-Blackwell. "Living Donor Liver Transplants May Drastically Decrease Mortality From Liver Failure." ScienceDaily. www.sciencedaily.com/releases/2008/09/080904215857.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins