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New Marker For Raised Intracranial Pressure

Date:
September 13, 2008
Source:
BioMed Central
Summary:
Magnetic resonance imaging measurements of the thickness of the optic nerve sheath are a good marker for raised intracranial pressure. New research shows that a retro-bulbar optic nerve sheath diameter above 5.82mm predicts raised ICP in 90 percent of cases.

Magnetic resonance imaging (MRI) measurements of the thickness of the optic nerve sheath are a good marker for raised intracranial pressure (ICP). New research published in BioMed Central's open access journal Critical Care shows that a retro-bulbar optic nerve sheath diameter (ONSD) above 5.82mm predicts raised ICP in 90% of cases.

The dural sheath surrounding the optic nerve communicates with the subarachnoid space and distends when ICP is elevated. Thomas Geeraerts, from Addenbrooke's Hospital, Cambridge, led a team who investigated whether MRI can be used to precisely measure the diameter of the optic nerve and its sheath. He said, "Raised ICP is frequent in conditions such as stroke, liver failure and meningitis. It is associated with increased mortality and poor neurological outcomes. As a result, the early detection and treatment of raised ICP is critical, but often challenging. Our MRI-based technique provides a useful, non-invasive solution".

The early detection of raised ICP can be very difficult when invasive devices are not available. As the authors report, "Clinical signs of raised ICP such as headache, vomiting and drowsiness are not specific and are often difficult to interpret. In sedated patients, clinical signs frequently appear well after the internal damage has been done. Optic nerve sheath distension could be an early, reactive and sensitive sign of raised ICP".

The authors carried out a retrospective blinded analysis of brain MR images in a prospective cohort of 38 patients requiring ICP monitoring after traumatic brain injury and 36 healthy controls. Geeraerts said, "We found that ONSD measurement was able to provide a quantitative estimate of the likelihood of significant cranial hypertension".


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Thomas Geeraerts, Virginia FJ Newcombe, Jonathan P Coles, Maria Giulia Abate, Iain E Perkes, Peter JA Hutchinson, Jo G Outtrim, Dot A Chatfield and David K Menon. Using T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure. Critical Care, 2008; (in press)

Cite This Page:

BioMed Central. "New Marker For Raised Intracranial Pressure." ScienceDaily. ScienceDaily, 13 September 2008. <www.sciencedaily.com/releases/2008/09/080910210531.htm>.
BioMed Central. (2008, September 13). New Marker For Raised Intracranial Pressure. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/09/080910210531.htm
BioMed Central. "New Marker For Raised Intracranial Pressure." ScienceDaily. www.sciencedaily.com/releases/2008/09/080910210531.htm (accessed July 24, 2014).

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