Featured Research

from universities, journals, and other organizations

Untapped Potential Of Antidepressants For Cancer

Date:
September 13, 2008
Source:
ecancermedicalscience
Summary:
A comprehensive review of current scientific literature has suggested that antidepressants can help the human body fight cancer by boosting its own immune response, amongst other mechanisms.

A comprehensive review of current scientific literature, published in the peer-reviewed journal ecancer, has suggested that antidepressants can help the human body fight cancer by boosting its own immune response, amongst other mechanisms.

Related Articles


Not only this but they can help with side effects from chemotherapy such as aiding sleep, stimulating appetite, combating pain and avoiding depression.

Antidepressants work by affecting levels of chemicals known as prostaglandins. These are ephemeral, infinitesimal signallers self-regulating every cell in the body, including those serving mood and immunity. When first discovered they were perceived as a master switch, but are now believed to regulate every component of cellular microanatomy and physiology, including those of the organelles, cytoskeleton, proteins, enzymes, nucleic acids and mitochondria.

Prostaglandins are responsible, paradoxically, for both cell function and dysfunction. Excessive prostaglandin synthesis depresses immune function and may induce cancer.

An ideal anticancer agent would inhibit prostaglandins in such a manner as to shut down the pathogenesis of cancer. The article indicates that antidepressants have such properties.

Report author, Dr Julian Lieb of Vermont, USA, concludes that antidepressants have the potential to arrest, prevent, reverse and palliate cancer. He also points out that short of that they have many other uses in cancer care.

Antidepressants can reduce the severity and frequency of hot flushes in patients treated with chemotherapy, and venlafaxine (Effexor) remit acute neurosensory symptoms secondary to oxaliplatin chemotherapy. The monoamine oxidase inhibitors deprenyl and clorgyline protect nonmalignant cells from ionizing radiation and chemotherapy toxicity, and such antidepressants as nefadazone are capable of reversing chemotherapy-induced vomiting.

The report notes that as the response to antidepressants is highly specific, many patients require multiple trials before responding. It found that some subjects are non-responsive to all antidepressants, and some may relapse due to getting used to the drug. However, adjusting prostaglandins can induce both pro and anti-cancer actions. The constant presence of this paradox means that antidepressants may be capable of initiating or accelerating cancer and thus maintaining close clinical observation and limiting the duration of drug trials is essential.

The review also points out that epidemiological studies have failed to confirm the suspicion that antidepressants may induce breast cancer. However, breast cancer has been reported in three men taking selective serotonin reuptake inhibitors.

Dr Lieb added: “Wherever prostaglandin-synthesizing enzymes convert arachidonic acid to prostaglandins there are possible sites of action of antidepressants. By maintaining these enzymes within physiological limits, antidepressants shut down the mechanisms of carcinogenesis. Considerable evidence now shows that antidepressants are cytotoxic, cytostatic, convert multidrug resistant cells to sensitive, and protect nonmalignant cells from ionizing radiation and chemotherapy.

Antidepressants have potent pain relieving properties alone, or through enhancing narcotics, and they enhance sleep, appetite and occasionally energy. Their immuno-stimulating and antimicrobial properties may help with infection secondary to chemotherapy or radiation. Alleviation of anxiety, depression, fear of death, recrimination and remorse by antidepressants can be very beneficial, though care must be taken to monitor for negative effects such as intensification of depression or pain. Overall, the positive effects of antidepressants in cancer therapeutics far outweigh the negatives.”


Story Source:

The above story is based on materials provided by ecancermedicalscience. Note: Materials may be edited for content and length.


Cite This Page:

ecancermedicalscience. "Untapped Potential Of Antidepressants For Cancer." ScienceDaily. ScienceDaily, 13 September 2008. <www.sciencedaily.com/releases/2008/09/080911142620.htm>.
ecancermedicalscience. (2008, September 13). Untapped Potential Of Antidepressants For Cancer. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2008/09/080911142620.htm
ecancermedicalscience. "Untapped Potential Of Antidepressants For Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/09/080911142620.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins